Evidence map›Paper›PMID 24619025›Full record

ArticleScientific reports2014

Damaging effects of multi-walled carbon nanotubes on pregnant mice with different pregnancy times.

Wei Qi, Juanjuan Bi, Xiaoyong Zhang, Jing Wang, Jianjun Wang, Peng Liu, Zhan Li, Wangsuo Wu

Abstract read
In one paragraph

Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Nanoparticles at the maternal-fetal interface.Molecular and cellular endocrinology · 2023
    Review
  9. Article
  10. Risk of maternal exposure to mixed air pollutants during pregnancy for congenital heart diseases in offspring.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2022
    Article
  11. Teratological effects of titanium dioxide nanoparticles in mice embryo.Environmental science and pollution research international · 2022
    Article
  12. Article
  13. Fetotoxicity of Nanoparticles: Causes and Mechanisms.Nanomaterials (Basel, Switzerland) · 2021
    Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wei QiRadiochemistry Laboratory, Lanzhou University, Lanzhou, Gansu, China, 730000.
Juanjuan BiRadiochemistry Laboratory, Lanzhou University, Lanzhou, Gansu, China, 730000.
Xiaoyong ZhangDepartment of Chemistry and Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Tsinghua University, Beijing, China, 100084.
Jing WangRadiochemistry Laboratory, Lanzhou University, Lanzhou, Gansu, China, 730000.
Jianjun WangRadiochemistry Laboratory, Lanzhou University, Lanzhou, Gansu, China, 730000.
Peng LiuRadiochemistry Laboratory, Lanzhou University, Lanzhou, Gansu, China, 730000.
Zhan LiKey Laboratory of Chemistry of Northwestern Plant Resources, Key Laboratory for Natural Medicine of Gansu Province, Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, Gansu, China, 730000.
Wangsuo Wu1] Radiochemistry Laboratory, Lanzhou University, Lanzhou, Gansu, China, 730000 [2] State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, Gansu, China, 730000.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mechanism by which nanoparticles cross the placental barrier was studied by using isotopic tracers. The abortion rates and other related data were counted and analysed in pregnant mice with different pregnancy times. Results showed that oxidised multi-walled carbon nanotubes (oMWCNTs) crossed the placental barrier and entered the foetus body. The abortion rates in the pregnant mice depended on pregnancy times. The abortion rates in the first-time, second-time and fourth-time pregnant mice were 70%, 40% and 50%, respectively. The maternal body weight gain was inhibited until gestational ages of 13, 10 and 11 d. oMWCNTs decreased the serum progesterone level and increased the serum oestradiol level in a dose- and time-dependent manner. However, this effect decreased with gestational age. The histology and vascular endothelial growth factor/reactive oxygen species content in the placenta showed that oMWCNTs narrowed the blood vessel and decreased the number of blood vessels in the placenta.

Indexed as

Abortion, SpontaneousAnimalsBody WeightDose-Response Relationship, DrugEstradiolFemaleFetusGestational AgeMiceNanotubes, CarbonPlacentaPregnancyProgesteroneReactive Oxygen SpeciesVascular Endothelial Growth Factor AVasoconstrictionEstradiolNanotubes, CarbonProgesteroneReactive Oxygen SpeciesVascular Endothelial Growth Factor A

Identifiers

PMID24619025
PMCPMC3950636

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.