ArticlePloS one2014
Behavior modulates effective connectivity between cortex and striatum.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Human subthalamic nucleus in movement error detection and its evaluation during visuomotor adaptation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Trial
- Decoding the striatum of drug-naive patients with obsessive-compulsive disorder: a transcriptome and longitudinal functional magnetic resonance imaging study.Translational psychiatry · 2025Article
- Dynamics Learning Rate Bias in Pigeons: Insights from Reinforcement Learning and Neural Correlates.Animals : an open access journal from MDPI · 2024Article
- Altered Effective Connectivity Measured by Resting-State Functional Magnetic Resonance Imaging in Posterior Parietal-Frontal-Striatum Circuit in Patients With Disorder of Consciousness.Frontiers in neuroscience · 2021Article
- Lack of mutant huntingtin in cortical efferents improves behavioral inflexibility and corticostriatal dynamics in Huntington's disease mice.Journal of neurophysiology · 2019Article
- Translating striatal activity from brain slice to whole animal neurophysiology: A guide for neuroscience research integrating diverse levels of analysis.Journal of neuroscience research · 2019Review
- Corticostriatal network dysfunction in Huntington's disease: Deficits in neural processing, glutamate transport, and ascorbate release.CNS neuroscience & therapeutics · 2018Review
- Functional network stability and average minimal distance - A framework to rapidly assess dynamics of functional network representations.Journal of neuroscience methods · 2018Article
- Efficient communication dynamics on macro-connectome, and the propagation speed.Scientific reports · 2018Article
- Granger causality supports abnormal functional connectivity of beta oscillations in the dorsolateral striatum and substantia nigra pars reticulata in hemiparkinsonian rats.Experimental brain research · 2017Article
- Alterations in Functional Cortical Hierarchy in Hemiparkinsonian Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Dysregulated corticostriatal activity in open-field behavior and the head-twitch response induced by the hallucinogen 2,5-dimethoxy-4-iodoamphetamine.Neuropharmacology · 2017Article
- A novel cross-frequency coupling detection method using the generalized Morse wavelets.Journal of neuroscience methods · 2016Article
- High-Degree Neurons Feed Cortical Computations.PLoS computational biology · 2016Article
- Rich-Club Organization in Effective Connectivity among Cortical Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Untangling Cortico-Striatal Connectivity and Cross-Frequency Coupling in L-DOPA-Induced Dyskinesia.Frontiers in systems neuroscience · 2016Article
- Functional Clusters, Hubs, and Communities in the Cortical Microconnectome.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
- Brain activity mapping at multiple scales with silicon microprobes containing 1,024 electrodes.Journal of neurophysiology · 2015Article
- Multiplex networks of cortical and hippocampal neurons revealed at different timescales.PloS one · 2014Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
It has been notoriously difficult to understand interactions in the basal ganglia because of multiple recurrent loops. Another complication is that activity there is strongly dependent on behavior, suggesting that directional interactions, or effective connections, can dynamically change. A simplifying approach would be to examine just the direct, monosynaptic projections from cortex to striatum and contrast this with the polysynaptic feedback connections from striatum to cortex. Previous work by others on effective connectivity in this pathway indicated that activity in cortex could be used to predict activity in striatum, but that striatal activity could not predict cortical activity. However, this work was conducted in anesthetized or seizing animals, making it impossible to know how free behavior might influence effective connectivity. To address this issue, we applied Granger causality to local field potential signals from cortex and striatum in freely behaving rats. Consistent with previous results, we found that effective connectivity was largely unidirectional, from cortex to striatum, during anesthetized and resting states. Interestingly, we found that effective connectivity became bidirectional during free behaviors. These results are the first to our knowledge to show that striatal influence on cortex can be as strong as cortical influence on striatum. In addition, these findings highlight how behavioral states can affect basal ganglia interactions. Finally, we suggest that this approach may be useful for studies of Parkinson's or Huntington's diseases, in which effective connectivity may change during movement.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.