Clinical application of whole-genome sequencing: proceed with care.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

1. Impact of SLCO1B1 Pharmacogenetic Testing on Patient and Healthcare Outcomes: A Systematic Review.Clinical pharmacology and therapeutics · 2019
   Pooled it
2. Evaluating Approaches for Communication About Genomic Influences on Body Weight.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2015
   Trial
3. Reflexive standardization and the resolution of uncertainty in the genomics clinic.Social studies of science · 2023
   Article
4. Rapid Identification of Drug-Resistant Tuberculosis Genes Using Direct PCR Amplification and Oxford Nanopore Technology Sequencing.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2022
   Article
5. Practicing precision medicine with intelligently integrative clinical and multi-omics data analysis.Human genomics · 2020
   Article
6. More than Moore's Mores: Computers, Genomics, and the Embrace of Innovation.Journal of the history of biology · 2018
   Article
7. Comprehensive Cancer-Predisposition Gene Testing in an Adult Multiple Primary Tumor Series Shows a Broad Range of Deleterious Variants and Atypical Tumor Phenotypes.American journal of human genetics · 2018
   Article
8. New technologies to uncover the molecular basis of disorders of sex development.Molecular and cellular endocrinology · 2018
   Review
9. Validation of CZECANCA (CZEch CAncer paNel for Clinical Application) for targeted NGS-based analysis of hereditary cancer syndromes.PloS one · 2018
   Article
10. Finding the right balance between precision medicine and personalized care.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2017
    Review
11. Longevity-Associated FOXO3 Genotype and its Impact on Coronary Artery Disease Mortality in Japanese, Whites, and Blacks: A Prospective Study of Three American Populations.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017
    Observational
12. Sharpening Precision Medicine by a Thorough Interrogation of Metabolic Individuality.Computational and structural biotechnology journal · 2016
    Review
13. Next-Generation Testing for Cancer Risk: Perceptions, Experiences, and Needs Among Early Adopters in Community Healthcare Settings.Genetic testing and molecular biomarkers · 2015
    Article
14. Challenges of using next generation sequencing in newborn screening.Genetics research · 2015
    Article
15. Genetic research on biospecimens poses minimal risk.Trends in genetics : TIG · 2015
    Review
16. Whole genome sequencing in pharmacogenomics.Frontiers in pharmacology · 2015
    Article
17. The Human Genome Project, and recent advances in personalized genomics.Risk management and healthcare policy · 2015
    Review
18. Is the ``$1000 Genome'' really $1000? Understanding the full benefits and costs of genomic sequencing.Technology and health care : official journal of the European Society for Engineering and Medicine · 2015
    Article
19. Genetic Addiction Risk Score (GARS): molecular neurogenetic evidence for predisposition to Reward Deficiency Syndrome (RDS).Molecular neurobiology · 2014
    Article
20. Utility before business.Genetics in medicine : official journal of the American College of Medical Genetics · 2014
    Article

Corrections and comments

• Comment on
  Clinical interpretation and implications of whole-genome sequencing.2014

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as