Evidence map›Paper›PMID 24618934›Full record

ArticleThe Pediatric infectious disease journal2014

Late-onset bloodstream infections in hospitalized term infants.

Daniela Testoni, Madoka Hayashi, Michael Cohen-Wolkowiez, Daniel K Benjamin, Renato D Lopes, Reese H Clark, Daniel K Benjamin, P Brian Smith

Open access · greenAbstract read
In one paragraph

Article in The Pediatric infectious disease journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Prevention and treatment of neonatal nosocomial infections.Maternal health, neonatology and perinatology · 2017
    Review
  8. Article
  9. Article
  10. Characteristics of late-onset sepsis in the NICU: does occupancy impact risk of infection?Journal of perinatology : official journal of the California Perinatal Association · 2016
    Article
  11. Article
  12. Article
  13. Pathology of Neonatal Non- albicans Candidiasis: Autopsy Study and Literature Review.Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Daniela TestoniFrom the *Duke Clinical Research Institute, Durham, NC; †Division of Neonatal Medicine, Escola Paulista de Medicina-Universidade Federal de São Paulo, São Paulo, Brazil; ‡Department of Pediatrics, Duke University, Durham, NC; §Pediatrix-Obstetrix Center for Research and Education, Sunrise, FL; and ¶Department of Economics, Clemson University, Clemson, SC.
Madoka Hayashi
Michael Cohen-Wolkowiez
Daniel K Benjamin
Renato D Lopes
Reese H Clark
Daniel K Benjamin
P Brian Smith
Duke University · USClinical Research Institute · USMednax (United States) · US

Funding

Duke CTSA (Composite)UL1TR001117 · NCATS · DUKE UNIVERSITY · PI BOULWARE, LEIGH E, LI, JENNIFER S · 2013 to 2017
$41.3M
Prevention of Invasive Candidiasis: PK, Safety, and Neurodevelopmental OutcomesR01HD057956 · NICHD · DUKE UNIVERSITY · PI BENJAMIN, DANIEL K. · 2008 to 2012
$2.8M
Mentorship of early-career pediatricians in quantitiative methods and therapeuticK24HD058735 · NICHD · DUKE UNIVERSITY · PI BENJAMIN, DANIEL K. · 2009 to 2018
$1.5M
Clinical Practice Data to Aid Narrow Therapeutic Index Drug ClassificationU01FD004858 · FDA · DUKE UNIVERSITY · PI COHEN-WOLKOWIEZ, MICHAEL · 2013 to 2014
$497k
Pharmacokinetics and Pharmacodynamics of Antibiotics in Premature InfantsK23HD064814 · NICHD · DUKE UNIVERSITY · PI COHEN-WOLKOWIEZ, MICHAEL · 2010 to 2013
$474k
ASPE HHS 1R18AE000028-01FDA HHS 1U01FD004858-01FDA HHS U01 FD004858NCATS NIH HHS UL1 TR001117NCATS NIH HHS UL1TR001117NICHD NIH HHS 1K23HD064814NICHD NIH HHS 1K24HD058735-05NICHD NIH HHS 1R01HD057956-05NICHD NIH HHS HHSN275201000003INICHD NIH HHS K23 HD064814NICHD NIH HHS K24 HD058735NICHD NIH HHS L40 HD069892NICHD NIH HHS R01 HD057956
6 · The paper itself

Abstract

backgroundThe epidemiology and incidence of late-onset blood stream infections (BSIs) in premature infants have been described, but studies describing late-onset BSI in term infants are sparse. We sought to describe the pathogens, incidence, risk factors and mortality of late-onset BSI in hospitalized term infants.

methodsA cohort study was conducted of infants ≥37 weeks gestational age and ≤120 days of age discharged from Pediatrix Medical Group neonatal intensive care units from 1997 to 2010. We examined all cultures obtained from day of life 4-120 and used multivariable regression to assess risk factors for late-onset BSI.

resultsWe found a total of 206,019 infants cared for between day of life 4 and 120, and the incidence of late-onset BSI was 2.7/1000 admissions. We identified Gram-positive organisms in 64% of the cultures and Gram-negative organisms in 26%. We found a decreased risk of late-onset BSI in infants with the following characteristics: small for gestational age, delivery by Cesarean, antenatal antibiotic use and discharged in the later years of the study. Late-onset BSI increased the risk of death after controlling for confounders [odds ratio 8.43 (95% confidence interval 4.42-16.07)].

conclusionOur data highlight the importance of late-onset BSI in hospitalized term infants. We identified Gram-positive organisms as the most common pathogen, and late-onset BSI was an independent risk factor for death.

Indexed as

Anti-Bacterial AgentsBacteremiaCesarean SectionCohort StudiesFemaleFungemiaGram-Negative Bacterial InfectionsGram-Positive Bacterial InfectionsHospitalizationHumansIncidenceInfantInfant, NewbornInfant, Small for Gestational AgeMaleMycosesAnti-Bacterial Agents

Identifiers

PMID24618934
PMCPMC4160433
OpenAlexW1964728899

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.