ArticlePloS one2014
Variable virulence factors in Burkholderia pseudomallei (melioidosis) associated with human disease.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
78 citing papers in PubMed, 2 syntheses or guidelines pooled it, 129 citations in OpenAlex.
- Whole Genome Sequencing and Comparative Genomics of the Emerging PathogenPathogens (Basel, Switzerland) · 2025Pooled it
- Central nervous system melioidosis: A systematic review of individual participant data of case reports and case series.PLoS neglected tropical diseases · 2019Pooled it
- Outcomes of patients with suspected or confirmed melioidosis: A prospective multinational, multicenter, observational study.PLoS neglected tropical diseases · 2026Observational
- Characterization of an isogenicInfection and immunity · 2026Article
- BimAIJID regions · 2025Article
- Neuromelioidosis outbreak in Tamil Nadu, India: an investigation of transmission with genomic insights.The Lancet regional health. Southeast Asia · 2025Article
- Review
- Virulence of Burkholderia pseudomallei ATS2021 Unintentionally Imported to United States in Aromatherapy Spray.Emerging infectious diseases · 2024Article
- The Genomic Epidemiology of ClinicalPathogens (Basel, Switzerland) · 2024Article
- Bone and joint infections due to melioidosis; diagnostic and management strategies to optimise outcomes.PLoS neglected tropical diseases · 2024Article
- Burkholderia pseudomallei BipD modulates host mitophagy to evade killing.Nature communications · 2024Article
- Epidemiology and genetic diversity of Burkholderia pseudomallei from Riau Province, Indonesia.PLoS neglected tropical diseases · 2024Article
- Review
- Burkholderia pseudomallei and melioidosis.Nature reviews. Microbiology · 2024Review
- Phylogenetic and phenotypic characterization ofFrontiers in microbiology · 2024Article
- Clinical Manifestations and Genomic Evaluation of Melioidosis Outbreak among Children after Sporting Event, Australia.Emerging infectious diseases · 2023Review
- The Epidemiological, Clinical, and Microbiological Features of Patients withTropical medicine and infectious disease · 2023Article
- Melioidosis Queensland: An analysis of clinical outcomes and genomic factors.PLoS neglected tropical diseases · 2023Article
- Article
- Variable Virulence Genes in Clinical Isolates ofJournal of laboratory physicians · 2023Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Burkholderia pseudomallei is a Gram-negative environmental bacterium that causes melioidosis, a potentially life-threatening infectious disease affecting mammals, including humans. Melioidosis symptoms are both protean and diverse, ranging from mild, localized skin infections to more severe and often fatal presentations including pneumonia, septic shock with multiple internal abscesses and occasionally neurological involvement. Several ubiquitous virulence determinants in B. pseudomallei have already been discovered. However, the molecular basis for differential pathogenesis has, until now, remained elusive. Using clinical data from 556 Australian melioidosis cases spanning more than 20 years, we identified a Burkholderia mallei-like actin polymerization bimA(Bm) gene that is strongly associated with neurological disease. We also report that a filamentous hemagglutinin gene, fhaB3, is associated with positive blood cultures but is negatively correlated with localized skin lesions without sepsis. We show, for the first time, that variably present virulence factors play an important role in the pathogenesis of melioidosis. Collectively, our study provides a framework for assessing other non-ubiquitous bacterial virulence factors and their association with disease, such as candidate loci identified from large-scale microbial genome-wide association studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.