ArticlePloS one2014
Changes in oxidative stress markers and biological markers of muscle injury with aging at rest and in response to an exhaustive exercise.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 3 of them syntheses that pooled it.
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Who cites it
50 citing papers in PubMed, 3 syntheses or guidelines pooled it, 94 citations in OpenAlex.
- Effects of exhaustive and/or strenuous exercise on aging-related molecular and physiological biomarkers: a systematic review and meta-analysis.Biogerontology · 2026Pooled it
- Effect of Different Exercise Modalities on Oxidative Stress: A Systematic Review.BioMed research international · 2021Pooled it
- Wet, volatile, and dry biomarkers of exercise-induced muscle fatigue.BMC musculoskeletal disorders · 2016Pooled it
- Evaluation of the Efficacy of Supplementation with Planox® Lemon Verbena Extract in Improving Oxidative Stress and Muscle Damage: A Randomized Double-Blind Controlled Trial.International journal of medical sciences · 2021Trial
- Trial
- Effect ofInternational journal of environmental research and public health · 2020Trial
- Effect of resistance training with different frequencies and detraining on muscular strength and oxidative stress biomarkers in older women.Age (Dordrecht, Netherlands) · 2015Trial
- (Poly)phenols: Mechanisms of action and efficacy of contemporary supplements for exercise recovery and performance.Experimental physiology · 2026Review
- Cognitive and biochemical responses to continuous moderate and extensive interval exercise in randomized elderly male rats.BMC sports science, medicine & rehabilitation · 2026Article
- Redox regulation in aging muscles: exercise as a key modulator to combat sarcopenia and frailty.Frontiers in cell and developmental biology · 2026Review
- The GPX3 rs3828599 genotype in combination with alcohol consumption and age helps identify a high-risk hypertension subgroup for antioxidant intervention.Journal of translational medicine · 2025Article
- Smartphone addiction and musculoskeletal associated disorders in university students: biomechanical measures and questionnaire survey analysis.European journal of medical research · 2025Article
- Oxidative Stress Promotes Axonal Atrophy through Alterations in Microtubules and EB1 Function.Aging and disease · 2024Article
- Association between dietary and behavioral-based oxidative balance score and phenotypic age acceleration: a cross-sectional study of Americans.Epidemiology and health · 2024Article
- Measures of Oxidative Status Markers in Relation to Age, Sex, and Season in Sick and Healthy Captive Asian Elephants in Thailand.Animals : an open access journal from MDPI · 2023Article
- DoesMedicina (Kaunas, Lithuania) · 2022Article
- Can Photobiomodulation Therapy (PBMT) Minimize Exercise-Induced Oxidative Stress? A Systematic Review and Meta-Analysis.Antioxidants (Basel, Switzerland) · 2022Review
- Impact of Hydrotherapy on Antioxidant Enzyme Activity in an Elderly Population.Geriatrics (Basel, Switzerland) · 2022Article
- Effects of High Intensity Exercise on Oxidative Stress and Antioxidant Status in Untrained Humans: A Systematic Review.Biology · 2021Review
- The Combined Effects of 6 Weeks of Jump Rope Interval Exercise and Dark Chocolate Consumption on Antioxidant Markers in Obese Adolescent Boys.Antioxidants (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study was to evaluate whether oxidative stress markers and biomarkers of muscle injury would be affected by aging at rest and in response to an incremental exhaustive exercise.
methodsFifteen young (20.3 ± 2.8 years) and fifteen older adults (65.1 ± 3.5 years) performed an incremental cycle ergometer test to exhaustion. Before and after exercise, oxidative stress [superoxide dismutase (SOD), glutathione peroxidase (GPX), glutathione reductase (GR), ascorbic acid, α-Tocopherol, malondialdehyde (MDA)] and muscle injury [creatine kinase (CK), lactate deshydrogenase (LDH)] biomarkers were assessed.
resultsAt rest, there was no difference in oxidative stress markers and LDH level between the groups, however CK was significantly higher in the young group than the elderly group (p<0.05). During recovery, in comparison with resting values, a significant increase in SOD (1092 ± 145.9 vs. 1243 ± 98 U/g Hb), GPX (67.4 ± 12.7 vs. 79.2 ± 15.6 U/g Hb) and GR (6.5 ± 0.9 vs. 7.7 ± 0.5 U/g Hb) activities were observed only in the young group (p<0.05). MDA has increased only in the older group (0.54 ± 0.2 vs. 0.79 ± 0.2 µmol/l) (p<0.01). CK increased in both groups (young group: 122.5 ± 22.2 vs. 161.9 ± 18.7 UI/l; older group: 88.8 ± 34.1 vs. 111.1 ± 25.9 UI/l) (p<0.01), however LDH has increased only in the young group (400.5 ± 22.2 vs. 485 ± 18.7 UI/l) (p<0.01) without alteration in the older group (382.8 ± 34.1 vs. 418.5 ± 25.9 UI/l).
conclusionsThese findings indicate that aging is associated with a decrease in antioxidant efficiency and an increase in oxidative stress damage. Furthermore, older adults would not more susceptible to exercise-induced muscle injury than young people.
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Registered trials
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