ArticlePloS one2014
Microgravity induces changes in microsome-associated proteins of Arabidopsis seedlings grown on board the international space station.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 49 citations in OpenAlex.
- Are we trapped on Earth: space and accelerated ageing.NPJ microgravity · 2025Review
- Exploring plant responses to altered gravity for advancing space agriculture.Plant communications · 2025Review
- Glycome profiling and immunohistochemistry uncover changes in cell walls of Arabidopsis thaliana roots during spaceflight.NPJ microgravity · 2023Article
- Microgravity enhances the phenotype of Arabidopsis zigzag-1 and reduces the Wortmannin-induced vacuole fusion in root cells.NPJ microgravity · 2022Article
- Space omics research in Europe: Contributions, geographical distribution and ESA member state funding schemes.iScience · 2022Review
- Use of Reduced Gravity Simulators for Plant Biological Studies.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Effects of Simulated Microgravity on the Proteome and Secretome of the Polyextremotolerant Black FungusFrontiers in genetics · 2021Article
- Root Skewing-Associated Genes Impact the Spaceflight Response ofFrontiers in plant science · 2020Article
- Test ofFrontiers in plant science · 2020Article
- A member of the CONSTANS-Like protein family is a putative regulator of reactive oxygen species homeostasis and spaceflight physiological adaptation.AoB PLANTS · 2019Article
- RNAseq Analysis of the Response ofFrontiers in plant science · 2019Article
- Novel, Moon and Mars, partial gravity simulation paradigms and their effects on the balance between cell growth and cell proliferation during early plant development.NPJ microgravity · 2018Article
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- The electrical network of maize root apex is gravity dependent.Scientific reports · 2015Article
- Spaceflight induces specific alterations in the proteomes of Arabidopsis.Astrobiology · 2015Article
- A Bird's-Eye View of Molecular Changes in Plant Gravitropism Using Omics Techniques.Frontiers in plant science · 2015Review
- Article
- Microsome-associated proteome modifications of Arabidopsis seedlings grown on board the International Space Station reveal the possible effect on plants of space stresses other than microgravity.Plant signaling & behavior · 2014Article
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The "GENARA A" experiment was designed to monitor global changes in the proteome of membranes of Arabidopsis thaliana seedlings subjected to microgravity on board the International Space Station (ISS). For this purpose, 12-day-old seedlings were grown either in space, in the European Modular Cultivation System (EMCS) under microgravity or on a 1 g centrifuge, or on the ground. Proteins associated to membranes were selectively extracted from microsomes and identified and quantified through LC-MS-MS using a label-free method. Among the 1484 proteins identified and quantified in the 3 conditions mentioned above, 80 membrane-associated proteins were significantly more abundant in seedlings grown under microgravity in space than under 1 g (space and ground) and 69 were less abundant. Clustering of these proteins according to their predicted function indicates that proteins associated to auxin metabolism and trafficking were depleted in the microsomal fraction in µg space conditions, whereas proteins associated to stress responses, defence and metabolism were more abundant in µg than in 1 g indicating that microgravity is perceived by plants as a stressful environment. These results clearly indicate that a global membrane proteomics approach gives a snapshot of the cell status and its signaling activity in response to microgravity and highlight the major processes affected.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.