ArticleBMC evolutionary biology2014
Diverse and potentially manipulative signalling with ascarosides in the model nematode C. elegans.
Article in BMC evolutionary biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Nematode Pheromones as Key Mediators of Behavior, Development, and Ecological Interactions.Biomolecules · 2025Review
- Natural genetic variation in the pheromone production ofProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Selection and gene flow shape niche-associated variation in pheromone response.Nature ecology & evolution · 2019Article
- A primer on pheromone signaling in Caenorhabditis elegans for systems biologists.Current opinion in systems biology · 2019Article
- Article
- Working with dauer larvae.WormBook : the online review of C. elegans biology · 2018Review
- Comparative Ascaroside Profiling of Caenorhabditis Exometabolomes Reveals Species-Specific (ω) and (ω - 2)-Hydroxylation Downstream of Peroxisomal β-Oxidation.The Journal of organic chemistry · 2018Article
- Rictor/TORC2 mediates gut-to-brain signaling in the regulation of phenotypic plasticity in C. elegans.PLoS genetics · 2018Article
- Reimagining pheromone signalling in the model nematode Caenorhabditis elegans.PLoS genetics · 2017Article
- Mutation independently affects reproductive traits and dauer larvae development in mutation accumulation lines of Caenorhabditis elegans.Development genes and evolution · 2017Article
- Pheromone modulates two phenotypically plastic traits - adult reproduction and larval diapause - in the nematode Caenorhabditis elegans.BMC evolutionary biology · 2017Article
- The Natural Biotic Environment ofGenetics · 2017Review
- Strongyloides ratti and S. venezuelensis - rodent models of Strongyloides infection.Parasitology · 2017Review
- Fluorescent Beads Are a Versatile Tool for Staging Caenorhabditis elegans in Different Life Histories.G3 (Bethesda, Md.) · 2016Article
- Caging and Uncaging Genetics.PLoS biology · 2016Article
- The evolution of plasticity of dauer larva developmental arrest in the nematode Caenorhabditis elegans.Ecology and evolution · 2015Article
- Article
- Small molecule signals mediate social behaviors inJournal of neurogeneticsReview
- Invertebrate models of behavioural plasticity and human disease.Brain and neuroscience advancesReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnimals use environmental information to make developmental decisions to maximise their fitness. The nematode Caenorhabditis elegans measures its environment to decide between arresting development as dauer larvae or continuing to grow and reproduce. Worms are thought to use ascarosides as signals of population density and this signalling is thought to be a species-wide honest signal. We compared recently wild C. elegans lines' dauer larva arrest when presented with the same ascaroside signals and in different food environments.
resultsWe find that the hitherto canonical dauer larva response does not hold among these lines. Ascaroside molecules can, depending on the food environment, both promote and repress dauer larva formation. Further, these recently wild C. elegans lines also produce ascaroside mixtures that induce a wide diversity of dauer larva formation responses. We further find that the lines differ in the quantity and ratios of ascaroside molecules that they release. Some of the dauer larva formation responses are consistent with dishonest signalling.
conclusionsTogether, the results suggest that the idea that dauer larva formation is an honestly-signalled C. elegans-wide effect does not hold. Rather, the results suggest that ascaroside-based signalling is a public broadcast information system, but where the correct interpretation of that information depends on the worms' context, and is a system open to dishonest signalling.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.