Trial reportEnvironmental health perspectives2014
Hemodynamic, autonomic, and vascular effects of exposure to coarse particulate matter air pollution from a rural location.
Trial report in Environmental health perspectives, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Effects of controlled, acute exposure to air pollutants on heart rate variability in humans: a meta-regression and methodological recommendations.BMC public health · 2026Pooled it
- Short-term exposure to particulate matter on heart rate variability in humans: a systematic review of crossover and controlled studies.Environmental science and pollution research international · 2021Pooled it
- Endotoxin and β-1,3-d-Glucan in Concentrated Ambient Particles Induce Rapid Increase in Blood Pressure in Controlled Human Exposures.Hypertension (Dallas, Tex. : 1979) · 2015Trial
- Effect of wood smoke exposure on vascular function and thrombus formation in healthy fire fighters.Particle and fibre toxicology · 2014Trial
- The characteristics of coarse particulate matter air pollution associated with alterations in blood pressure and heart rate during controlled exposures.Journal of exposure science & environmental epidemiologyTrial
- Campfire Smoke as a Plausible Trigger for Vasospastic Angina: Insights From a Case Report.The American journal of case reports · 2025Article
- The Correlation between Oral Health and Air Pollution: A Systematic Review.Dentistry journal · 2024Review
- Environmental Exposome and Atrial Fibrillation: Emerging Evidence and Future Directions.Circulation research · 2024Review
- Cigarette smoking and air pollution exposure and their effects on cardiovascular diseases.Frontiers in public health · 2023Review
- New Homogeneous Spatial Areas Identified Using Case-Crossover Spatial Lag Grid Differences between Aerosol Optical Depth-PMAtmosphere · 2022Article
- Ambient air pollution and endocrinologic disorders in childhood.Annals of pediatric endocrinology & metabolism · 2021Article
- Particulate matter inhalation and the exacerbation of cardiopulmonary toxicity due to metabolic disease.Experimental biology and medicine (Maywood, N.J.) · 2021Review
- Long-term exposure to outdoor air pollution and risk factors for cardiovascular disease within a cohort of older men in Perth.PloS one · 2021Article
- INSIDE Project: Individual Air Pollution Exposure, Extracellular Vesicles Signaling and Hypertensive Disorder Development in Pregnancy.International journal of environmental research and public health · 2020Article
- Blood-derived extracellular vesicles isolated from healthy donors exposed to air pollution modulate in vitro endothelial cells behavior.Scientific reports · 2020Article
- Environmental determinants of cardiovascular disease: lessons learned from air pollution.Nature reviews. Cardiology · 2020Review
- Contribution of Satellite-Derived Aerosol Optical Depth PMAtmosphere · 2020Article
- Gaseous Pollutants and Particulate Matter (PM) in Ambient Air and the Number of New Cases of Type 1 Diabetes in Children and Adolescents in the Pomeranian Voivodeship, Poland.BioMed research international · 2020Article
- Elderly Mortality and Exposure to Fine Particulate Matter and Ozone.Journal of Korean medical science · 2019Article
- The impact of polar fraction of the fine particulate matter on redox responses in different rat tissues.Environmental science and pollution research international · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundFine particulate matter (PM) air pollution is associated with numerous adverse health effects, including increased blood pressure (BP) and vascular dysfunction. Coarse PM substantially contributes to global air pollution, yet differs in characteristics from fine particles and is currently not regulated. However, the cardiovascular (CV) impacts of coarse PM exposure remain largely unknown.
objectivesOur goal was to elucidate whether coarse PM, like fine PM, is itself capable of eliciting adverse CV responses.
methodsWe performed a randomized double-blind crossover study in which 32 healthy adults (25.9 ± 6.6 years of age) were exposed to concentrated ambient coarse particles (CAP; 76.2 ± 51.5 μg/m(3)) in a rural location and filtered air (FA) for 2 hr. We measured CV outcomes during, immediately after, and 2 hr postexposures.
resultsBoth systolic (mean difference = 0.32 mmHg; 95% CI: 0.05, 0.58; p = 0.021) and diastolic BP (0.27 mmHg; 95% CI: 0.003, 0.53; p = 0.05) linearly increased per 10 min of exposure during the inhalation of coarse CAP when compared with changes during FA exposure. Heart rate was on average higher (4.1 bpm; 95% CI: 3.06, 5.12; p < 0.0001) and the ratio of low-to-high frequency heart rate variability increased (0.24; 95% CI: 0.07, 0.41; p = 0.007) during coarse particle versus FA exposure. Other outcomes (brachial flow-mediated dilatation, microvascular reactive hyperemia index, aortic hemodynamics, pulse wave velocity) were not differentially altered by the exposures.
conclusionsInhalation of coarse PM from a rural location is associated with a rapid elevation in BP and heart rate during exposure, likely due to the triggering of autonomic imbalance. These findings add mechanistic evidence supporting the biological plausibility that coarse particles could contribute to the triggering of acute CV events.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.