ArticleMalaria journal2014
Correlation of biomarkers for parasite burden and immune activation with acute kidney injury in severe falciparum malaria.
Article in Malaria journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Clinical characteristics and outcome of malaria-associated acute kidney injury in adult patients: a systematic review and meta analysis.Malaria journal · 2026Pooled it
- Risk factors for acute kidney injury at presentation among children with CNS malaria: a case control study.Malaria journal · 2022Trial
- Prevalence of acute kidney injury and its associated factors among malaria patients admitted to public hospitals in the Ilu Aba Bora and Bedelle Zones of Oromia region, Southwest Ethiopia.BMC infectious diseases · 2026Article
- Article
- Reevaluating malaria severity metrics: insights from PfHRP2-derived biomass estimates in Ghanaian children.Malaria journal · 2026Article
- Malaria-Associated Acute Kidney Injury in a Low-Endemic Region: A Case Series of Five ImportedCase reports in infectious diseases · 2026Article
- CD8Frontiers in cellular and infection microbiology · 2025Article
- Clinical, immune and genetic risk factors of malaria-associated acute kidney injury in Zambian children: A study protocol.PloS one · 2025Observational
- The myxozoansFrontiers in cellular and infection microbiology · 2024Article
- Novel Experimental Mouse Model to Study Malaria-Associated Acute Kidney Injury.Pathogens (Basel, Switzerland) · 2023Article
- Clinical Characteristics of Acute Kidney Injury Associated with Tropical Acute Febrile Illness.Tropical medicine and infectious disease · 2023Article
- A comprehensive rhythmicity analysis of host proteins and immune factors involved in malaria pathogenesis to decipher the importance of host circadian clock in malaria.Frontiers in immunology · 2023Article
- Kidney complications of parasitic diseases.Nature reviews. Nephrology · 2022Review
- Experimental malaria-associated acute kidney injury is independent of parasite sequestration and resolves upon antimalarial treatment.Frontiers in cellular and infection microbiology · 2022Article
- suPAR to Risk-Stratify Patients With Malaria.Frontiers in immunology · 2022Review
- Potential Biomarkers in Diagnosis of Renal Acanthamoebiasis.International journal of molecular sciences · 2021Article
- Pathomechanisms in the Kidneys in Selected Protozoan Parasitic Infections.International journal of molecular sciences · 2021Review
- Acute kidney injury secondary to severe delayed haemolysis in intravenous artesunate use for severe malaria.BMJ case reports · 2021Article
- Immunopathology of Acute Kidney Injury in Severe Malaria.Frontiers in immunology · 2021Review
- Malaria-Associated Acute Kidney Injury in African Children: Prevalence, Pathophysiology, Impact, and Management Challenges.International journal of nephrology and renovascular disease · 2021Review
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Authors and funding
13 authors at 7 institutions in 5 countries.
Funding
Abstract
backgroundAcute kidney injury (AKI) complicating severe Plasmodium falciparum malaria occurs in up to 40% of adult patients. The case fatality rate reaches 75% in the absence of renal replacement therapy (RRT). The precise pathophysiology of AKI in falciparum malaria remains unclear. Histopathology shows acute tubular necrosis with localization of host monocytes and parasitized red blood cells in the microvasculature. This study explored the relationship of plasma soluble urokinase-type plasminogen activator receptor (suPAR), as a proxy-measure of mononuclear cell activation, and plasma P. falciparum histidine rich protein 2 (PfHRP2), as a measure of sequestered parasite burden, with AKI in severe malaria.
methodsAdmission plasma suPAR and PfHRP2 concentrations were assessed in Bangladeshi adults with severe falciparum malaria (n=137). Patients were stratified according to AKI severity based on admission creatinine clearance.
resultsA total of 106 (77%) patients had AKI; 32 (23%), 42 (31%) and 32 (23%) were classified into 'mild, 'moderate' and 'severe' AKI groups, respectively. Plasma suPAR and PfHRP2 concentrations increased with AKI severity (test-for-trend P <0.0001) and correlated with other markers of renal dysfunction. Admission plasma suPAR and PfHRP2 concentrations were higher in patients who later required RRT (P <0.0001 and P=0.0004, respectively). In a multivariate analysis, both increasing suPAR and PfHRP2 were independently associated with increasing urine neutrophil gelatinase-associated lipocalin concentration, a marker of acute tubular necrosis (β=16.54 (95% CI 6.36-26.71) and β=0.07 (0.02-0.11), respectively).
conclusionsBoth sequestered parasite burden and immune activation contribute to the pathogenesis of AKI in severe falciparum malaria.
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