ArticleRegenerative medicine2014
Multipotential stromal cell abundance in cellular bone allograft: comparison with fresh age-matched iliac crest bone and bone marrow aspirate.
Article in Regenerative medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Regional Gene Therapy for Bone Tissue Engineering: A Current Concepts Review.Bioengineering (Basel, Switzerland) · 2025Review
- Reduced Sodium Portions Favor Osteogenic Properties and Cytocompatibility of 45S5-Based Bioactive Glass Particles.Biomimetics (Basel, Switzerland) · 2023Article
- Bone healing: Advances in biology and technology.OTA international : the open access journal of orthopaedic trauma · 2021Article
- Hurdles to uptake of mesenchymal stem cells and their progenitors in therapeutic products.The Biochemical journal · 2020Review
- Epidemiology, Clinical Assessments, and Current Treatments of Nonunions.Current osteoporosis reports · 2020Review
- Methods of Cryoprotectant Preservation: Allogeneic Cellular Bone Grafts and Potential Effects.BioMed research international · 2019Review
- Bone Marrow-Harvesting Technique Influences Functional Heterogeneity of Mesenchymal Stem/Stromal Cells and Cartilage Regeneration.The American journal of sports medicine · 2018Article
- T cell immunomodulation by clinically used allogeneic human cancellous bone fragments: a potential novel immunotherapy tool.Scientific reports · 2018Article
- Tissue Engineering and Cell-Based Therapies for Fractures and Bone Defects.Frontiers in bioengineering and biotechnology · 2018Review
- Fabrication and Characterization of Polyphosphazene/Calcium Phosphate Scaffolds Containing Chitosan Microspheres for Sustained Release of Bone Morphogenetic Protein 2 in Bone Tissue Engineering.Tissue engineering and regenerative medicine · 2017Article
- GEORG-SCHMORL-PRIZE OF THE GERMAN SPINE SOCIETY (DWG) 2016: Comparison of in vitro osteogenic potential of iliac crest and degenerative facet joint bone autografts for intervertebral fusion in lumbar spinal stenosis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2017Article
- Mesenchymal Stem Cell Alterations in Bone Marrow Lesions in Patients With Hip Osteoarthritis.Arthritis & rheumatology (Hoboken, N.J.) · 2016Article
- Bone repair with skeletal stem cells: rationale, progress to date and clinical application.Therapeutic advances in musculoskeletal disease · 2016Review
- Clinical evaluation of an allogeneic bone matrix containing viable osteogenic cells in patients undergoing one- and two-level posterolateral lumbar arthrodesis with decompressive laminectomy.Journal of orthopaedic surgery and research · 2016Article
- Collagen-containing scaffolds enhance attachment and proliferation of non-cultured bone marrow multipotential stromal cells.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2016Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
aimTo enumerate and characterize multipotential stromal cells (MSCs) in a cellular bone allograft and compare with fresh age-matched iliac crest bone and bone marrow (BM) aspirate. MATERIALS &
methodsMSC characterization used functional assays, confocal/scanning electron microscopy and whole-genome microarrays. Resident MSCs were enumerated by flow cytometry following enzymatic extraction.
resultsAllograft material contained live osteocytes and proliferative bone-lining cells defined as MSCs by phenotypic and functional capacities. Without cultivation/expansion, the allograft displayed an 'osteoinductive' molecular signature and the presence of CD45(-)CD271(+)CD73(+)CD90(+)CD105(+) MSCs; with a purity over 100-fold that of iliac crest bone. In comparison with BM, MSC numbers enzymatically released from 1 g of cellular allograft were equivalent to approximately 45 ml of BM aspirate.
conclusionCellular allograft bone represents a unique nonimmune material rich in MSCs and osteocytes. This osteoinductive graft represents an attractive alternative to autograft bone or composite/synthetic grafts in orthopedics and broader regenerative medicine settings.
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Registered trials
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