ArticleHPB : the official journal of the International Hepato Pancreato Biliary Association2014
Critical review of the prognostic significance of pathological variables in patients undergoing resection for colorectal liver metastases.
Article in HPB : the official journal of the International Hepato Pancreato Biliary Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Histopathological prognostic factors for colorectal liver metastases: A systematic review and meta-analysis of observational studies.Histology and histopathology · 2021Pooled it
- Computational pathology: A survey review and the way forward.Journal of pathology informatics · 2024Review
- Colorectal liver metastasis with bile duct tumor thrombus discovered 15 years post primary tumor resection: a case report and literature review.International cancer conference journal · 2023Article
- Nerve Density and Neuronal Biomarkers in Cancer.Cancers · 2022Review
- ACE Inhibitor Therapy Does Not Influence the Survival Outcomes of Patients with Colorectal Liver Metastases Following Liver Resection.Journal of gastrointestinal cancer · 2021Article
- Retrospective cohort study of statin therapy effect on resected colorectal liver metastases.World journal of gastrointestinal surgery · 2020Article
- Comparison of the eighth version of the American Joint Committee on Cancer manual to the seventh version for colorectal cancer: A retrospective review of our data.World journal of clinical oncology · 2018Article
- The Prognostic Value of Varying Definitions of Positive Resection Margin in Patients with Colorectal Cancer Liver Metastases.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2018Article
- Colon liver metastasis complicated with tumor thrombus in the bile duct: A case report.International journal of surgery case reports · 2018Article
- Rectal Cancer in Patients Under 50 Years of Age.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2017Article
- Resection margin influences the outcome of patients with bilobar colorectal liver metastases.World journal of hepatology · 2016Article
- Parenchyma-sparing hepatectomy (PSH) versus non-PSH for bilobar liver metastases of colorectal cancer.Annals of gastroenterologyArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to identify prognostic factors, particularly pathological variables, that influence disease-free and overall survival following resection for colorectal liver metastases (CRLM).
methodsPatients undergoing CRLM resection from January 2005 to December 2011 were included. Data analysed included information on demographics, laboratory results, operative findings, histopathological features and survival.
resultsA total of 259 patients were included. Of these, 138 (53.3%) patients developed recurrent disease, of which 95 died. The median length of follow-up in the remaining patients was 28 months (range: 12-96 months). There were significant associations between recurrence and higher tumour number (P = 0.002), presence of perineural invasion (P = 0.009) and positive margin (R1) resection (P = 0.002). Multivariate analysis showed all three prognostic factors to be independent predictors of disease-free survival. Significantly poorer overall survival after hepatic resection for CRLM was observed in patients undergoing hemi-hepatectomy or more radical resection (P = 0.021), patients with a higher number of tumours (P = 0.024) and patients with perineural invasion (P < 0.001). Multivariate analysis showed perineural invasion to be the only independent predictor of overall survival.
conclusionsThe presence of perineural invasion, multiple tumours and an R1 margin were associated with recurrent disease. Perineural invasion was also an independent prognostic factor with respect to overall survival.
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