ArticleMobile genetic elements2014
Quadruplex-forming DNA sequences spread by retrotransposons may serve as genome regulators.
Article in Mobile genetic elements, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Metabolic disease variants rewire gene regulation through disruption of DNA G-quadruplex structures.Genome biology · 2026Article
- Factors determining chromosomal localization of transposable elements in plants.Plant biology (Stuttgart, Germany) · 2025Review
- Non-canonical DNA in human and other ape telomere-to-telomere genomes.Nucleic acids research · 2025Article
- Non-canonical DNA in human and other ape telomere-to-telomere genomes.bioRxiv : the preprint server for biology · 2025Article
- Telomeric retrotransposons show propensity to form G-quadruplexes in various eukaryotic species.Mobile DNA · 2023Article
- Noncanonical DNA structures are drivers of genome evolution.Trends in genetics : TIG · 2023Review
- Genome-wide characterization of i-motifs and their potential roles in the stability and evolution of transposable elements in rice.Nucleic acids research · 2022Article
- Quadruplex-Forming Motif Inserted into 3'UTR ofBiology · 2021Article
- Sequence properties of certain GC rich avian genes, their origins and absence from genome assemblies: case studies.BMC genomics · 2019Article
- Stable and Conserved G-Quadruplexes in the Long Terminal Repeat Promoter of Retroviruses.ACS infectious diseases · 2019Article
- Thermodynamically stable and genetically unstable G-quadruplexes are depleted in genomes across species.Nucleic acids research · 2019Article
- Quadruplex DNA in long terminal repeats in maize LTR retrotransposons inhibits the expression of a reporter gene in yeast.BMC genomics · 2018Article
- Article
- Genome-wide analysis of G-quadruplexes in herpesvirus genomes.BMC genomics · 2016Article
- RNA as a fundamental component of interphase chromosomes: could repeats prove key?Current opinion in genetics & development · 2016Review
- Transposable elements and G-quadruplexes.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2015Review
- VisualTE: a graphical interface for transposable element analysis at the genomic scale.BMC genomics · 2015Article
- Guanine quadruplexes are formed by specific regions of human transposable elements.BMC genomics · 2014Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transposable elements (TEs) are ubiquitous genome inhabitants in eukaryotes. Increasing evidence shows that TEs are involved in regulatory networks of eukaryotic cells and contribute to genome evolution. Recently, we reported that many plant long-terminal repeat (LTR) retrotransposons contain DNA quadruplex-forming sequences at precise positions inside their LTRs and that quadruplexes are better preserved in evolutionary younger elements. As quadruplexes can modulate molecular processes, quadruplexes found at specific distances upstream and downstream from the endogenous TE promoter can affect transcription of the element. Moreover, quadruplexes found in solo LTRs, as well as in 3' ends of 5'-truncated copies of LINE-1 elements, can affect expression of neighboring genes. Here, we propose that this way retrotransposons can serve as vehicles for spread of DNA quadruplexes. Quadruplexes can thus fulfill a dual regulatory role-to influence both the retrotransposons carrying them and the neighboring host genes, e.g., by direct effect on transcription or by modifying the local chromatin state. Additionally, four-stranded DNA structures may serve as hotspots for recombination-based genome rearrangements.
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