Evidence map›Paper›PMID 24616831›Full record

ArticleJournal of periodontal & implant science2014

Omega 3 fatty acids as a host modulator in chronic periodontitis patients: a randomised, double-blind, palcebo-controlled, clinical trial.

Girish D Deore, Abhijit N Gurav, Rahul Patil, Abhijeet R Shete, Ritam S Naiktari, Saurabh P Inamdar

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of periodontal & implant science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04389931 (Effect of Omega 3 as an Immunomodulator Adjunct to Periodontal Debridement), which is not on this map. Cited by 38 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 12 pooled it
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04389931 nacompletednot on this mapstarted 2016, after this paper: background citation

Effect of Omega 3 as an Immunomodulator Adjunct to Periodontal Debridement: A Randomized Controlled Clinical Trial

TypeinterventionalSponsorUniversidad Nacional Andres BelloRan2016 to 2016Enrolled18ConditionsPeriodontitisArmsLactose tab, Omega 3
3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 12 syntheses or guidelines pooled it, 69 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Girish D DeoreDepartment of Periodontology, Tatyasaheb Kore Dental College and Research Centre, New Pargaon, Kolhapur, Maharashtra, India.ORCID 0000-0001-8034-3641
Abhijit N GuravDepartment of Periodontology, Tatyasaheb Kore Dental College and Research Centre, New Pargaon, Kolhapur, Maharashtra, India.ORCID 0000-0002-1530-5160
Rahul PatilDepartment of Periodontology, Tatyasaheb Kore Dental College and Research Centre, New Pargaon, Kolhapur, Maharashtra, India.ORCID 0000-0002-9066-5705
Abhijeet R SheteDepartment of Periodontology, Tatyasaheb Kore Dental College and Research Centre, New Pargaon, Kolhapur, Maharashtra, India.ORCID 0000-0001-6871-9749
Ritam S NaiktariDepartment of Periodontology, Tatyasaheb Kore Dental College and Research Centre, New Pargaon, Kolhapur, Maharashtra, India.ORCID 0000-0002-0923-4829
Saurabh P InamdarDepartment of Periodontology, Tatyasaheb Kore Dental College and Research Centre, New Pargaon, Kolhapur, Maharashtra, India.ORCID 0000-0003-1584-1403
Tatyasaheb Kore Dental College and Research Centre · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePeriodontitis is an infectious disease caused predominantly by gram-negative anerobes. The host inflammatory response to these bacteria causes alveolar bone loss that is characterized as periodontitis. Omega-3 fatty acids (ω-3 FAs) have anti-inflammatory properties, thus have been used to treat some chronic inflammatory diseases such as cardiovascular disease and rheumatoid arthritis. We aimed to evaluate the effect of dietary supplementation with ω-3 FAs as a host modulating agent in patients with chronic periodontitis.

methodsSixty otherwise healthy subjects with moderate and severe chronic periodontitis were enrolled in our randomised, double-blind, placebo-controlled trial. The control group (CG, n=30) was treated with scaling and root planing (SRP) and given a placebo; the treatment group (TG, n=30) was treated with SRP and dietary supplementation of ω-3 FAs (one 300 mg tablet daily for 12 weeks). Periodontal clinical parameters and serum C-reactive protein (CRP) levels were evaluated in all patients at baseline, a 6-week and 12-week period after treatment.

resultsA significant reduction in the gingival index, sulcus bleeding index, pocket depth, and clinical attachment level was found in the TG compared to the CG at a 12-week period. However, no statistically significant changes in serum CRP levels were found.

conclusionsOur findings suggest that ω-3 FAs can successfully reduce gingival inflammation, pocket depth, and attachment level gain. Dietary supplementation with ω-3 FAs may have potential benefits as a host modulatory agent in the prevention and/or adjunctive management of chronic periodontitis.

Indexed as

Chronic periodontitisC-reactive proteinOmega-3 fatty acids

Identifiers

PMID24616831
PMCPMC3945394
OpenAlexW1984980039

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.