ArticleParkinson's disease2014
Mortality in levodopa-treated Parkinson's disease.
Article in Parkinson's disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of non-invasive brain stimulation on walking and balance ability in Parkinson's patients: A systematic review and meta-analysis.Frontiers in aging neuroscience · 2022Pooled it
- Effect of Early Levodopa Treatment on Mortality in People with Parkinson's Disease.Movement disorders clinical practice · 2024Article
- Sex Differences in the Speech of Persons With and Without Parkinson's Disease.American journal of speech-language pathology · 2024Article
- CD36-Binding Amphiphilic Nanoparticles for Attenuation of Alpha Synuclein-Induced Microglial Activation.Advanced nanobiomed research · 2022Article
- What Is the Most Important and Impactful Paper Related to Movement Disorder Therapy Published in the 20th Century?Movement disorders clinical practice · 2021Article
- Article
- The Queensland Parkinson's Project: An Overview of 20 Years of Mortality from Parkinson's Disease.Journal of movement disorders · 2021Article
- Pharmacological Treatment of Early Motor Manifestations of Parkinson Disease (PD).Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020Review
- The Effect of Human Umbilical Cord Mesenchymal Stromal Cells in Protection of Dopaminergic Neurons from Apoptosis by Reducing Oxidative Stress in the Early Stage of a 6-OHDA-Induced Parkinson's Disease Model.Cell transplantation · 2019Article
- Article
- Depression in Parkinson's disease: A case-control study.PloS one · 2018Article
- 14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening.Human molecular genetics · 2016Article
- Premotor Symptoms as Predictors of Outcome in Parkinsons Disease: A Case-Control Study.PloS one · 2016Article
- An evidence-based approach to identify aging-related genes in Caenorhabditis elegans.BMC bioinformatics · 2015Article
- Clinical and Epidemiological Factors Associated with Mortality in Parkinson's Disease in a Brazilian Cohort.Parkinson's disease · 2015Article
- Parkinson's Disease and development of levodopa induced motor complications: Influence of baseline features and first medical approach.Porto biomedical journalArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Parkinson's disease (PD) is associated with increased mortality despite many advances in treatment. Following the introduction of levodopa in the late 1960's, many studies reported improved or normalized mortality rates in PD. Despite the remarkable symptomatic benefits provided by levodopa, multiple recent studies have demonstrated that PD patients continue to die at a rate in excess of their peers. We undertook this retrospective study of 211 deceased PD patients to determine the factors associated with mortality in levodopa-treated PD. Our findings confirm that PD is associated with increased mortality in both men and women. Unlike the majority of other mortality studies, we found that women have a greater reduction in lifespan compared to men. We also found that patients with early onset PD (onset at the age of 50 or before) have reduced survival relative to PD patients with later ages of onset. A final important finding is that survival is equal in PD patients treated with levodopa early (within 2 years or less of PD onset) versus later.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.