ArticleFrontiers in neural circuits2014
Dopamine control of pyramidal neuron activity in the primary motor cortex via D2 receptors.
Article in Frontiers in neural circuits, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 61 citations in OpenAlex.
- Separation of paranoid from nonparanoid delusions.European archives of psychiatry and clinical neuroscience · 2026Article
- Impaired peri-infarct long-term potentiation in anaesthetized rats suggests alternative mechanisms of post-stroke recovery.The Journal of physiology · 2026Article
- The role of dopamine-sensitive motor cortical circuits in the development and execution of skilled forelimb movements.iScience · 2026Article
- Dopaminergic Degeneration Differentially Modulates Primary Motor Cortex Activity and Motor Behavior in Hemiparkinsonian Rats.Brain sciences · 2025Article
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- Multi-scale and cross-dimensional TMS mapping: A proof of principle in patients with Parkinson's disease and deep brain stimulation.Frontiers in neuroscience · 2023Article
- Astrocyte metabolism and signaling pathways in the CNS.Frontiers in neuroscience · 2023Review
- Endogenous dopamine transmission is crucial for motor skill recovery after stroke.IBRO neuroscience reports · 2022Article
- Oscillatory waveform sharpness asymmetry changes in motor thalamus and motor cortex in a rat model of Parkinson's disease.Experimental neurology · 2022Article
- Relationship of the Nigrostriatal Tract with the Motor Function and the Corticospinal Tract in Chronic Hemiparetic Stroke Patients: A Diffusion Tensor Imaging Study.Healthcare (Basel, Switzerland) · 2022Article
- Acupuncture Regulates Symptoms of Parkinson's DiseaseFrontiers in aging neuroscience · 2022Article
- Cell Type-Specific Decrease of the Intrinsic Excitability of Motor Cortical Pyramidal Neurons in Parkinsonism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Article
- Dopaminergic Modulation of Forced Running Performance in Adolescent Rats: Role of Striatal D1 and Extra-striatal D2 Dopamine Receptors.Molecular neurobiology · 2021Article
- Evaluation of Cerebellar Function and Integrity of Adult Rats After Long-Term Exposure to Aluminum at Equivalent Urban Region Consumption Concentrations.Biological trace element research · 2021Article
- Ten-Hour Exposure to Low-Dose Ketamine Enhances Corticostriatal Cross-Frequency Coupling and Hippocampal Broad-Band Gamma Oscillations.Frontiers in neural circuits · 2018Article
- Article
- Monoaminergic Modulation of Motor Cortex Function.Frontiers in neural circuits · 2017Review
- Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by α-synuclein overexpression.Acta neuropathologica communications · 2015Article
- Topography and collateralization of dopaminergic projections to primary motor cortex in rats.Experimental brain research · 2015Article
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The primary motor cortex (M1) is involved in fine voluntary movements control. Previous studies have shown the existence of a dopamine (DA) innervation in M1 of rats and monkeys that could directly modulate M1 neuronal activity. However, none of these studies have described the precise distribution of DA terminals within M1 functional region nor have quantified the density of this innervation. Moreover, the precise role of DA on pyramidal neuron activity still remains unclear due to conflicting results from previous studies regarding D2 effects on M1 pyramidal neurons. In this study we assessed in mice the neuroanatomical characteristics of DA innervation in M1 using unbiased stereological quantification of DA transporter-immunostained fibers. We demonstrated for the first time in mice that DA innervates the deep layers of M1 targeting preferentially the forelimb representation area of M1. To address the functional role of the DA innervation on M1 neuronal activity, we performed electrophysiological recordings of single neurons activity in vivo and pharmacologically modulated D2 receptor activity. Local D2 receptor activation by quinpirole enhanced pyramidal neuron spike firing rate without changes in spike firing pattern. Altogether, these results indicate that DA innervation in M1 can increase neuronal activity through D2 receptor activation and suggest a potential contribution to the modulation of fine forelimb movement. Given the demonstrated role for DA in fine motor skill learning in M1, our results suggest that altered D2 modulation of M1 activity may be involved in the pathophysiology of movement disorders associated with disturbed DA homeostasis.
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