ArticleJournal of Korean medical science2014
Recent trends of antigenic variation in Bordetella pertussis isolates in Korea.
Article in Journal of Korean medical science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- A systematic review of the burden of pertussis in South Korea.Human vaccines & immunotherapeutics · 2021Pooled it
- Pertussis in the Post-COVID-19 Era: Resurgence, Diagnosis, and Management.Infection & chemotherapy · 2025Review
- Comparative Evaluation of Recombinant and Acellular Pertussis Vaccines in a Murine Model.Vaccines · 2024Article
- Genomic characterization ofMicrobial genomics · 2023Article
- Analysis of antibiotic sensitivity and resistance genes of Bordetella pertussis in Chinese children.Medicine · 2021Article
- Recent increase in pertussis incidence in Korea: an age-period-cohort analysis.Epidemiology and health · 2021Article
- Comparative genomics of whole-cell pertussis vaccine strains from India.BMC genomics · 2020Article
- [Antimicrobial susceptibility and antigen genotypes of Bordetella pertussis strains isolated from neonates].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2019Article
- Bordetella pertussis: new concepts in pathogenesis and treatment.Current opinion in infectious diseases · 2016Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pertussis is a representative vaccine-preventable disease. However, there have been recent outbreaks in countries where even higher vaccination against the disease. One reason is the emergence of antigenic variants, which are different to vaccine type. In Korea, reported cases have rapidly increased since 2009. Therefore, we analyzed genotype of strains isolated in 2011-2012 by multilocus sequence typing method. As expected, the genotype profiles of tested genes dramatically changed. The major sequence type changed from ST1 to ST2, and new sequence type (ST8) appeared. In the minimum spanning tree, recent isolates belonging to the ACC-I-ST3 subgroup were detected that were composed of ST2, ST3, and ST6. In particular, the ST2 frequency increased to 81%. The novel ST8 was linked to the increased frequency of ST2. In addition, toxic strains carrying the ptxP3 promoter type were confirmed. This ptxP3 type emerged from 2009 and its frequency had increased to 100% in 2012. Based on these results, it can be inferred that the genotypic changes in the currently circulating strains are strongly associated with the recent increasing of pertussis in Korea. Therefore, the surveillance system should be strengthened, and genetic characterization of the isolates should be expanded to the whole genome sequence level.
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Registered trials
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