ArticleProceedings of the National Academy of Sciences of the United States of America2014
Charge separation and charge delocalization identified in long-living states of photoexcited DNA.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 119 citations in OpenAlex.
- UV photodamage pathways and the evolutionary selection of thymine over uracil in early genetic systems.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Strand Structure Controls Photoinduced Self-Repair of RNA Uracil Dimers.The journal of physical chemistry letters · 2026Article
- Accurate Prediction of Photoinduced Electron Transfer Timescales with Nonadiabatic Microcanonical Rate Theory.The journal of physical chemistry letters · 2026Article
- Factors Affecting the Population of Excited Charge Transfer States in Adenine/Guanine Dinucleotides: A Joint Computational and Transient Absorption Study.Biomolecules · 2024Article
- The photoactivated dynamics of dGpdC and dCpdG sequences in DNA: a comprehensive quantum mechanical study.Chemical science · 2024Article
- On the Use of the Intrinsic DNA Fluorescence for Monitoring Its Damage: A Contribution from Fundamental Studies.ACS omega · 2024Review
- Photoinduced charge separation and DNA self-repair depend on sequence directionality and stacking pattern.Chemical science · 2024Article
- Unraveling Excited State Dynamics of a Single-Stranded DNA-Assembled Conjugated Polyelectrolyte.The journal of physical chemistry letters · 2023Article
- Article
- Sequence dependent UV damage of complete pools of oligonucleotides.Scientific reports · 2023Article
- Exciton decay mechanism in DNA single strands: back-electron transfer and ultrafast base motions.Chemical science · 2022Article
- Remote Photodamaging of DNA by Photoinduced Energy Transport.Chembiochem : a European journal of chemical biology · 2022Review
- Adenine Radical Cation Formation by a Ligand-Centered Excited State of an Intercalated Chromium Polypyridyl Complex Leads to Enhanced DNA Photo-oxidation.Journal of the American Chemical Society · 2021Article
- 2,6-diaminopurine promotes repair of DNA lesions under prebiotic conditions.Nature communications · 2021Article
- How Far Does Energy Migrate in DNA and Cause Damage? Evidence for Long-Range Photodamage to DNA.Angewandte Chemie (International ed. in English) · 2020Article
- UV-Induced Charge-Transfer States in Short Guanosine-Containing DNA Oligonucleotides.Chembiochem : a European journal of chemical biology · 2020Article
- Article
- Transferring the entatic-state principle to copper photochemistry.Nature chemistry · 2018Article
- Multiple Decay Mechanisms and 2D-UV Spectroscopic Fingerprints of Singlet Excited Solvated Adenine-Uracil Monophosphate.Chemistry (Weinheim an der Bergstrasse, Germany) · 2016Article
- Direct observation by time-resolved infrared spectroscopy of the bright and the dark excited states of the [Ru(phen)Chemical science · 2016Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Base stacking in DNA is related to long-living excited states whose molecular nature is still under debate. To elucidate the molecular background we study well-defined oligonucleotides with natural bases, which allow selective UV excitation of one single base in the strand. IR probing in the picosecond regime enables us to dissect the contribution of different single bases to the excited state. All investigated oligonucleotides show long-living states on the 100-ps time scale, which are not observable in a mixture of single bases. The fraction of these states is well correlated with the stacking probabilities and reaches values up to 0.4. The long-living states show characteristic absorbance bands that can be assigned to charge-transfer states by comparing them to marker bands of radical cation and anion spectra. The charge separation is directed by the redox potential of the involved bases and thus controlled by the sequence. The spatial dimension of this charge separation was investigated in longer oligonucleotides, where bridging sequences separate the excited base from a sensor base with a characteristic marker band. After excitation we observe a bleach of all involved bases. The contribution of the sensor base is observable even if the bridge is composed of several bases. This result can be explained by a charge delocalization along a well-stacked domain in the strand. The presence of charged radicals in DNA strands after light absorption may cause reactions--oxidative or reductive damage--currently not considered in DNA photochemistry.
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