Trial reportProceedings of the National Academy of Sciences of the United States of America2014
Photic memory for executive brain responses.
Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed.
- The Effects of Light Therapy on Cognitive Function and Stress in Women With Breast Cancer Before Systemic Treatment.Cancer medicine · 2025Trial
- Examining the Efficacy of Bright Light Therapy on Cognitive Function in Hematopoietic Stem Cell Transplant Survivors.Journal of biological rhythms · 2022Trial
- Acute exposure to blue wavelength light during memory consolidation improves verbal memory performance.PloS one · 2017Trial
- Thin-film optical notch filter spectacle coatings for the treatment of migraine and photophobia.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2016Trial
- Regional activity within the human amygdala varies with season, mood and illuminance.Nature communications · 2025Article
- Relationships between light exposure and aspects of cognitive function in everyday life.Communications psychology · 2025Article
- A method for setting the melanopsin and rhodopsin content in commercial LED sources to investigate the effects of ambient light on behavior.Behavior research methods · 2025Article
- Effects of Sensory-Enhanced Acute Exercise on Affective Characteristics of Employees.Behavioral sciences (Basel, Switzerland) · 2025Article
- Article
- Article
- Prefrontal cortex neurons encode ambient light intensity differentially across regions and layers.Nature communications · 2024Article
- The cognitive impact of light: illuminating ipRGC circuit mechanisms.Nature reviews. Neuroscience · 2024Review
- Customized designed notch filters and applied effects on glare and contrast sensitivity in patients with dry eye syndrome.International ophthalmology · 2023Article
- Article
- Light as a Modulator of Non-Image-Forming Brain Functions-Positive and Negative Impacts of Increasing Light Availability.Clocks & sleep · 2023Review
- Light at night and cause-specific mortality risk in Mainland China: a nationwide observational study.BMC medicine · 2023Article
- Predicting ischemic stroke risk from atrial fibrillation based on multi-spectral fundus images using deep learning.Frontiers in cardiovascular medicine · 2023Article
- The effects of light colour on female rabbit reproductive performance and the expression of key genes in follicular development.Journal of animal science and technology · 2022Article
- The role of melanopsin photoreception on visual attention linked pupil responses.The European journal of neuroscience · 2022Article
- Current Insights into Optimal Lighting for Promoting Sleep and Circadian Health: Brighter Days and the Importance of Sunlight in the Built Environment.Nature and science of sleep · 2022Review
Corrections and comments
- Commented on by
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Light is a powerful stimulant for human alertness and cognition, presumably acting through a photoreception system that heavily relies on the photopigment melanopsin. In humans, evidence for melanopsin involvement in light-driven cognitive stimulation remains indirect, due to the difficulty to selectively isolate its contribution. Therefore, a role for melanopsin in human cognitive regulation remains to be established. Here, sixteen participants underwent consecutive and identical functional MRI recordings, during which they performed a simple auditory detection task and a more difficult auditory working memory task, while continuously exposed to the same test light (515 nm). We show that the impact of test light on executive brain responses depends on the wavelength of the light to which individuals were exposed prior to each recording. Test-light impact on executive responses in widespread prefrontal areas and in the pulvinar increased when the participants had been exposed to longer (589 nm), but not shorter (461 nm), wavelength light, more than 1 h before. This wavelength-dependent impact of prior light exposure is consistent with recent theories of the light-driven melanopsin dual states. Our results emphasize the critical role of light for cognitive brain responses and are, to date, the strongest evidence in favor of a cognitive role for melanopsin, which may confer a form of "photic memory" to human cognitive brain function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.