Evidence map›Paper›PMID 24616423›Full record

ReviewProteomics. Clinical applications2014

Shotgun MS proteomic analysis of bronchoalveolar lavage fluid in normal subjects.

Elizabeth V Nguyen, Sina A Gharib, Lynn M Schnapp, David R Goodlett

Abstract readReview
In one paragraph

Review in Proteomics. Clinical applications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. The bronchoalveolar proteome changes in obesity.American journal of physiology. Lung cellular and molecular physiology · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Elizabeth V NguyenDepartment of Medicinal Chemistry, University of Washington, Seattle, WA, USA.
Sina A Gharib
Lynn M Schnapp
David R Goodlett

Funding

Variation in Human Innate ImmunityU54AI057141 · NIAID · UNIVERSITY OF WASHINGTON · PI STETSON, DANIEL B · 2003 to 2013
$102.3M
INSTITUTE FOR TRANSLATIONAL HEALTH SCIENCE (UL1): BPCAUL1RR025014 · NCRR · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2007 to 2011
$51.5M
Institute of Translational Health SciencesUL1TR000423 · NCATS · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2012 to 2016
$49.4M
Matrix remodeling in the lung during HIV infectionR01HL083481 · NHLBI · UNIVERSITY OF WASHINGTON · PI SCHNAPP, LYNN M · 2005 to 2009
$1.9M
NCATS NIH HHS UL1 TR000423NCRR NIH HHS 1S10RR-449017262NCRR NIH HHS UL1 RR025014NCRR NIH HHS UL1RR025014NHLBI NIH HHS HL083481NHLBI NIH HHS K24HL068796NHLBI NIH HHS R01 HL083481NIAID NIH HHS 1U54 447 AI57141NIAID NIH HHS U54 AI057141
6 · The paper itself

Abstract

We provide a review of proteomic techniques used to characterize the bronchoalveolar lavage fluid (BALF) proteome of normal healthy subjects. Bronchoalveolar lavage (BAL) is the most common technique for sampling the components of the alveolar space. The proteomic techniques used to study normal BALF include protein separation by 2DE, whereby proteins were identified by comparison to a reference gel as well as high pressure liquid chromatography (HPLC)-MS/MS, also known as shotgun proteomics. We summarize recent progress using shotgun MS technologies to define the normal BALF proteome. Surprisingly, we find that despite advances in shotgun proteomic technologies over the course of the last 10 years, which have resulted in greater numbers of proteins being identified, the functional landscape of normal BALF proteome was similarly described by all methods examined.

Indexed as

Bronchoalveolar Lavage FluidProteomicsChromatography, High Pressure LiquidHumansReference ValuesTandem Mass SpectrometryBronchoalveolar lavage fluidEpithelial lining fluidMS

Identifiers

PMID24616423
PMCPMC4239657

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.