Evidence map›Paper›PMID 24616307›Full record

Trial reportJournal of clinical oncology : official journal of the American Society of Clinical Oncology2014

Improving the care of children with advanced cancer by using an electronic patient-reported feedback intervention: results from the PediQUEST randomized controlled trial.

Joanne Wolfe, Liliana Orellana, E Francis Cook, Christina Ullrich, Tammy Kang, Jeffrey Russell Geyer, Chris Feudtner, Jane C Weeks, Veronica Dussel

2 registry-linked trialsOpen access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 92 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 12 pooled it
18.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03849066 completednot on this mapstarted 2019, after this paper: background citation

Enhancing Medication Safety in Children With Polypharmacy Using Parent- Reported Symptom Assessments

TypeobservationalSponsorUniversity of Colorado, DenverRan2019 to 2022Enrolled136ConditionsNeurologic Disorder, Chronic Disease, Pediatric DisorderArmsParent-Reported Symptom Assessment
NCT06991673 naenrolling by invitationnot on this mapstarted 2025, after this paper: background citation

Adolescent Surgery Roadmap Feasibility and Acceptability Study

TypeinterventionalSponsorUniversity of MichiganRan2025 to 2029Enrolled100ConditionsPediatric Surgical ProceduresArmsBehavioral Treatment
3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 12 syntheses or guidelines pooled it, 151 citations in OpenAlex.

  1. Pooled it
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  3. Psychological interventions for enhancing resilience in parents of children with cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Pooled it
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  7. Impact of Specialized Pediatric Palliative Care: A Systematic Review.Journal of pain and symptom management · 2020
    Pooled it
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  9. A systematic review of randomised controlled trials evaluating the use of patient-reported outcome measures (PROMs).Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2019
    Pooled it
  10. Pooled it
  11. Patient-reported outcome use in oncology: a systematic review of the impact on patient-clinician communication.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018
    Pooled it
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  13. Qualitative insights from patient/caregivers, and clinicians on routine use of the EQ-5D-Y-5L in clinical paediatric care-results from a pilot feasibility and acceptability trial.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026
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  20. Symptoms and Distress in Children With Advanced Cancer: Prospective Patient-Reported Outcomes From the PediQUEST Study.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2015
    Trial

32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Joanne WolfeJoanne Wolfe, Christina Ullrich, Jane C. Weeks, and Veronica Dussel, Dana-Farber Cancer Institute; Joanne Wolfe and Christina Ullrich, Boston Children's Hospital; Joanne Wolfe, Christina Ullrich, and Jane C. Weeks, Harvard Medical School; E. Francis Cook, Harvard School of Public Health, Boston, MA; Liliana Orellana, University of Buenos Aires; Veronica Dussel, Institute for Clinical Effectiveness and Health Policy, Buenos Aires, Argentina; Tammy Kang and Chris Feudtner, The Children's Hospital of Philadelphia and the University of Pennsylvania, Philadelphia, PA; and Jeffrey Russell Geyer, Seattle Children's Hospital, Fred Hutchinson Cancer Research Center, and University of Washington, Seattle, WA.
Liliana Orellana
E Francis Cook
Christina Ullrich
Tammy Kang
Jeffrey Russell Geyer
Chris Feudtner
Jane C Weeks
Veronica Dussel
Harvard University · USBoston Children's Hospital · USChildren's Hospital of Philadelphia · USDana-Farber Cancer Institute · USUniversity of Buenos Aires · ARUniversity of Pennsylvania · US

Funding

Improving Care for Children with Advanced CancerK07CA096746 · NCI · DANA-FARBER CANCER INSTITUTE · PI WOLFE, JOANNE · 2002 to 2006
$678k
NCI NIH HHS 1K07 CA096746-01NCI NIH HHS K07 CA096746
6 · The paper itself

Abstract

purposeThis study aimed to determine whether feeding back patient-reported outcomes (PROs) to providers and families of children with advanced cancer improves symptom distress and health-related quality of life (HRQoL). PATIENTS AND

methodsThis study was a parallel, multicentered pilot randomized controlled trial. At most once per week, children age ≥ 2 years old with advanced cancer or their parent completed the computer-based Pediatric Quality of Life and Evaluation of Symptoms Technology (PediQUEST) survey consisting of age- and respondent-adapted versions of the Memorial Symptom Assessment Scale (MSAS), Pediatric Quality of Life Inventory 4.0 Generic Core Scales (PedsQL4.0), and an overall Sickness question. In the intervention group (n = 51), oncologists and families received printed reports summarizing PROs; e-mails were sent to oncologists and subspecialists when predetermined scores were exceeded. No feedback was provided in the control group (n = 53). Primary outcomes included linear trends of MSAS, PedsQL4.0 total and subscale scores, and Sickness scores during 20 weeks of follow-up, along with child, parent, and provider satisfaction with PediQUEST feedback.

resultsFeedback did not significantly affect average MSAS, PedsQL4.0, or Sickness score trends. Post hoc subgroup analyses among children age ≥ 8 years who survived 20 weeks showed that feedback improved PedsQL4.0 emotional (+8.1; 95% CI, 1.8 to 14.4) and Sickness (-8.2; 95% CI, -14.2 to -2.2) scores. PediQUEST reports were valued by children, parents, and providers and contributed at least sometimes to physician initiation of a psychosocial consult (56%).

conclusionAlthough routine feedback of PROs did not significantly affect the child's symptoms or HRQoL, changes were in expected directions and improvements observed in emotional HRQoL through exploratory analyses were encouraging. Importantly, children, parents, and providers value PRO feedback.

Indexed as

Electronic Health RecordsPalliative CareChildChild, PreschoolFeedbackFemaleHumansMaleNeoplasmsPilot ProjectsQuality of LifeSickness Impact ProfileSymptom AssessmentTreatment Outcome

Identifiers

PMID24616307
PMCPMC3970170
OpenAlexW2149515678

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.