ReviewCold Spring Harbor perspectives in medicine2014
Pancreas transplantation: solid organ and islet.
Review in Cold Spring Harbor perspectives in medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Pancreas Transplant Recipients with and Without Pretransplant Alcohol Use Disorder: A Real-World Cohort Study.Medical sciences (Basel, Switzerland) · 2026Article
- Simultaneous kidney and pancreas transplantation: Current trends and challenges.World journal of transplantation · 2026Review
- Isolation of feline islets of Langerhans by selective osmotic shock produces glucose responsive islets.Frontiers in veterinary science · 2024Article
- Whole-Organ Pancreas and Islets Transplantations in UK: An Overview and Future Directions.Journal of clinical medicine · 2023Review
- Survival After Simultaneous Pancreas-Kidney Transplantation in Type 1 Diabetes: The Critical Role of Early Pancreas Allograft Function.Transplant international : official journal of the European Society for Organ Transplantation · 2022Article
- The MEK Inhibitor Trametinib Suppresses Major Histocompatibility Antigen-mismatched Rejection Following Pancreatic Islet Transplantation.Transplantation direct · 2020Article
- Engineering Strategies to Improve Islet Transplantation for Type 1 Diabetes Therapy.ACS biomaterials science & engineering · 2020Article
- Two-stage Enteric Exclusion to Salvage a Pancreas Transplant After an Early Post-transplant Leak.Cureus · 2019Article
- Extracellular matrix scaffold and hydrogel derived from decellularized and delipidized human pancreas.Scientific reports · 2018Article
- Recent progress in the use and tracking of transplanted islets as a personalized treatment for type 1 diabetes.Expert review of precision medicine and drug development · 2017Article
- Simultaneous pancreas and kidney transplantation: current trends and future directions.Current opinion in organ transplantation · 2015Review
- Immunological and technical considerations in application of alginate-based microencapsulation systems.Frontiers in bioengineering and biotechnology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transplantation of the pancreas, either as a solid organ or as isolated islets of Langerhans, is indicated in a small proportion of patients with insulin-dependent diabetes in whom severe complications develop, particularly severe glycemic instability and progressive secondary complications (usually renal failure). The potential to reverse diabetes has to be balanced against the morbidity of long-term immunosuppression. For a patient with renal failure, the treatment of choice is often a simultaneous transplant of the pancreas and kidney (SPK), whereas for a patient with glycemic instability, specifically hypoglycemic unawareness, the choice between a solid organ and an islet transplant has to be individual to the patient. Results of SPK transplantation are comparable to other solid-organ transplants (kidney, liver, heart) and there is evidence of improved quality of life and life expectancy, but the results of solitary pancreas transplantation and islets are inferior with respect to graft survival. There is some evidence of benefit with respect to the progression of secondary diabetic complications in patients with functioning transplants for several years.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.