ArticleAngewandte Chemie (International ed. in English)2014
Deracemization by simultaneous bio-oxidative kinetic resolution and stereoinversion.
Article in Angewandte Chemie (International ed. in English), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- One-Pot Chemoenzymatic Cascade for the Enantioselective C(1)-Allylation of Tetrahydroisoquinolines.Journal of the American Chemical Society · 2023Article
- Chemoenzymatic approaches to plant natural product inspired compounds.Natural product reports · 2022Review
- Visible-Light-Driven Catalytic Deracemization of Secondary Alcohols.Angewandte Chemie (International ed. in English) · 2021Article
- Review
- Recent trends in biocatalysis.Chemical Society reviews · 2021Review
- Bioinspired Diversification Approach Toward the Total Synthesis of Lycodine-Type Alkaloids.Journal of the American Chemical Society · 2021Article
- Highly enantioselective synthesis of (R)-1,3-butanediol via deracemization of the corresponding racemate by a whole-cell stereoinverting cascade system.Microbial cell factories · 2020Article
- Synthesis of enantiomerically pure alcohols and aminesCatalysis science & technology · 2019Article
- Generation of amine dehydrogenases with increased catalytic performance and substrate scope from ε-deaminating L-Lysine dehydrogenase.Nature communications · 2019Article
- Ultra-high throughput functional enrichment of large monoamine oxidase (MAO-N) libraries by fluorescence activated cell sorting.The Analyst · 2018Article
- Biocatalytic Oxidation Reactions: A Chemist's Perspective.Angewandte Chemie (International ed. in English) · 2018Review
- Amine dehydrogenases: efficient biocatalysts for the reductive amination of carbonyl compounds.Green chemistry : an international journal and green chemistry resource : GC · 2017Article
- Forward design of a complex enzyme cascade reaction.Nature communications · 2016Article
- Building Bridges: Biocatalytic C-C-Bond Formation toward Multifunctional Products.ACS catalysis · 2016Review
- Highly regio- and enantioselective multiple oxy- and amino-functionalizations of alkenes by modular cascade biocatalysis.Nature communications · 2016Article
- An (ChemCatChem · 2015Article
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12 authors.
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Abstract
Deracemization, that is, the transformation of a racemate into a single product enantiomer with theoretically 100% conversion and 100% ee, is an appealing but also challenging option for asymmetric synthesis. Herein a novel chemo-enzymatic deracemization concept by a cascade is described: the pathway involves two enantioselective oxidation steps and one non-stereoselective reduction step, enabling stereoinversion and a simultaneous kinetic resolution. The concept was exemplified for the transformation of rac-benzylisoquinolines to optically pure (S)-berbines. The racemic substrates were transformed to optically pure products (ee>97%) with up to 98% conversion and up to 88% yield of isolated product.
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