ArticleInternational urology and nephrology2014
Chronic ketamine treatment-induced changes in contractility characteristics of the mouse detrusor.
Article in International urology and nephrology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 11 citations in OpenAlex.
- Article
- How Ketamine Affects Livers of Pregnant Mice and Developing Mice?International journal of molecular sciences · 2017Article
- Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo understand bladder contractility changes induced by chronic ketamine treatment, noting the prevalence of its abuse worldwide.
methodsA mouse model of chronic ketamine treatment was used and detrusor strip contractility was measured. Rising and falling phases of contractile responses as well as maximal, average sustained and phasic contractions were measured.
resultsWhile maximal contractility of ketamine-treated strips was identical to the saline controls, the former displayed slower contraction rates under K(+)-Krebs, carbachol and electrical stimulation. The decay phase of electrically stimulated responses was also slower at most stimulation frequencies in the ketamine-treated strips. Greater sensitivity to varying the strengths of stimuli was observed in the ketamine-treated strips.
conclusionsAltered contractility characteristics of the bladder after chronic ketamine treatment were revealed, which could potentially be useful in the development of improved treatment regimens.
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