ReviewILAR journal2014
The armadillo as a model for peripheral neuropathy in leprosy.
Review in ILAR journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 49 citations in OpenAlex.
- Leprosy: Comprehensive insights into pathology, immunology, and cutting-edge treatment strategies, integrating nanoparticles and ethnomedicinal plants.Frontiers in pharmacology · 2024Review
- Qua vadis leprosy?The Indian journal of medical research · 2023Article
- Pathogenicity and virulence ofVirulence · 2022Review
- In vivo partial reprogramming by bacteria promotes adult liver organ growth without fibrosis and tumorigenesis.Cell reports. Medicine · 2022Article
- Mycobacterium leprae induces Schwann cell proliferation and migration in a denervated milieu following intracutaneous excision axotomy in nine-banded armadillos.Experimental neurology · 2022Article
- The Armadillo as a Model for Leprosy Nerve Function Impairment: Preventative and Therapeutic Interventions.Frontiers in medicine · 2022Article
- Treatment and Evaluation Advances in Leprosy Neuropathy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Review
- Susceptibility and resistance in leprosy: Studies in the mouse model.Immunological reviews · 2021Review
- Review
- Detection and Monitoring ofFrontiers in microbiology · 2021Article
- Skin tests for the detection of Mycobacterial infections: achievements, current perspectives, and implications for other diseases.Applied microbiology and biotechnology · 2021Review
- Development of LepReact, a defined skin test for paucibacillary leprosy and low-level M. leprae infection.Applied microbiology and biotechnology · 2020Article
- The Many Hosts of Mycobacteria 8 (MHM8): A conference report.Tuberculosis (Edinburgh, Scotland) · 2020Review
- Armadillos and leprosy: from infection to biological model.Revista do Instituto de Medicina Tropical de Sao Paulo · 2019Review
- Cell Biology of Intracellular Adaptation ofMicrobiology spectrum · 2019Review
- The cell fate regulator NUPR1 is induced by Mycobacterium leprae via type I interferon in human leprosy.PLoS neglected tropical diseases · 2019Article
- LepVax, a defined subunit vaccine that provides effective pre-exposure and post-exposure prophylaxis ofNPJ vaccines · 2018Article
- The Armadillo (Frontiers in immunology · 2018Article
- A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy.Cell · 2017Article
- Pauci- and Multibacillary Leprosy: Two Distinct, Genetically Neglected Diseases.PLoS neglected tropical diseases · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Leprosy (also known as Hansen's Disease) is a chronic infectious disease caused by Mycobacterium leprae that primarily targets the peripheral nervous system; skin, muscle, and other tissues are also affected. Other than humans, nine-banded armadillos (Dasypus novemcinctus) are the only natural hosts of M. leprae, and they are the only laboratory animals that develop extensive neurological involvement with this bacterium. Infection in the armadillo closely recapitulates many of the structural, physiological, and functional aspects of leprosy seen in humans. Armadillos can be useful models of leprosy for basic scientific investigations into the pathogenesis of leprosy neuropathy and its associated myopathies, as well as for translational research studies in piloting new diagnostic methods or therapeutic interventions. Practical and ethical constraints often limit investigation into human neuropathies, but armadillos are an abundant source of leprotic neurologic fibers. Studies with these animals may provide new insights into the mechanisms involved in leprosy that also might benefit the understanding of other demyelinating neuropathies. Although there is only a limited supply of armadillo-specific reagents, the armadillo whole genomic sequence has been completed, and gene expression studies can be employed. Clinical procedures, such as electrophysiological nerve conduction testing, provide a functional assessment of armadillo nerves. A variety of standard histopathological and immunopathological procedures including Epidermal Nerve Fiber Density (ENFD) analysis, Schwann Cell Density, and analysis for other conserved cellular markers can be used effectively with armadillos and will be briefly reviewed in this text.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.