ArticleCurrent osteoporosis reports2014
Atypical femoral fractures, bisphosphonates, and mechanical stress.
Article in Current osteoporosis reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- A novel CCL3-HMGB1 signaling axis regulating osteocyte RANKL expression in multiple myeloma.Haematologica · 2025Article
- Comparison of bone turnover suppression in atypical femoral fractures and osteoporotic hip fractures.Scientific reports · 2024Article
- Risk factors associated with low bone mineral density in children with idiopathic scoliosis: a scoping review.BMC musculoskeletal disorders · 2023Article
- Surveillance of atypical femoral fractures in a nationwide fracture register.Acta orthopaedica · 2022Article
- ATYPICAL FEMORAL FRACTURES DUE TO THE USE OF BISPHOSPHONATES: EPIDEMIOLOGIC STUDY IN A TERTIARY HOSPITAL.Acta ortopedica brasileira · 2022Article
- Exchange Nailing as Revision Surgery for Post-operative Non-union of Atypical Femoral Fractures: A Case Report and Treatment Strategy.Journal of orthopaedic case reports · 2021Article
- Localization of Atypical Femoral Fracture on Straight and Bowed Femurs.Journal of bone metabolism · 2019Article
- MMP14 is a novel target of PTH signaling in osteocytes that controls resorption by regulating soluble RANKL production.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- Atypical femoral fractures in Italy: a retrospective analysis in a large urban emergency department during a 7-year period (2007-2013).Journal of bone and mineral metabolism · 2017Article
- Atypical Femoral Shaft Fractures in Female Bisphosphonate Users Were Associated with an Increased Anterolateral Femoral Bow and a Thicker Lateral Cortex: A Case-Control Study.BioMed research international · 2017Article
- Protection From Glucocorticoid-Induced Osteoporosis by Anti-Catabolic Signaling in the Absence of Sost/Sclerostin.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2016Article
- Hypophosphatasia and the risk of atypical femur fractures: a case-control study.BMC musculoskeletal disorders · 2016Article
- Mechanical competence of ovariectomy-induced compromised bone after single or combined treatment with high-frequency loading and bisphosphonates.Scientific reports · 2015Article
- The Epidemiology of Metatarsal Fractures Among Older Females With Bisphosphonate Exposure.The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle SurgeonsArticle
- Atypical femoral fracture due to chronic use of bisphosphonates: case report.Revista brasileira de ortopediaArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atypical fractures are stress fractures occurring in the femoral shaft and closely related to bisphosphonate use. We here discuss their radiographic definition and different putative etiologies, apart from mechanical stress. Long time reduction of skeletal remodeling because of bisphosphonate use is thought to allow time for the bone to deteriorate mechanically, resulting in reduced toughness. However, the risk of atypical fracture diminishes rapidly after cessation of treatment, which suggests more acute effects of bisphosphonate use. Microdamage normally accumulates at areas of high stress. Possibly, ongoing bisphosphonate use reduces the ability to resorb and replace areas of microdamage by targeted remodeling. This could lead to crack propagation beyond a point of no return, ending in macroscopic stress fracture.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.