ReviewJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2014
A two-electron-shell game: intermediates of the extradiol-cleaving catechol dioxygenases.
Review in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Mimicking Extradiol Dioxygenase Reactivity on Iridium.Journal of the American Chemical Society · 2026Article
- Vitamin BACS central science · 2025Article
- Dioxygenase Chemistry in Nucleophilic Aldehyde Deformylations Utilizing Dicopper OJournal of the American Chemical Society · 2024Article
- Tyrosinases: a family of copper-containing metalloenzymes.Chemtexts · 2024Article
- Reversible Dioxygen Binding to Co(II) Complexes with Noninnocent Ligands.Inorganic chemistry · 2022Article
- Microbial degradation of halogenated aromatics: molecular mechanisms and enzymatic reactions.Microbial biotechnology · 2020Review
- Uno Ferro, a de novo Designed Protein, Binds Transition Metals with High Affinity and Stabilizes Semiquinone Radical Anion.Chemistry (Weinheim an der Bergstrasse, Germany) · 2019Article
- Cobalt Superoxo and Alkylperoxo Complexes Derived from Reaction of Ring-Cleaving Dioxygenase Models with OJournal of the American Chemical Society · 2019Article
- The role of halogen substituents and substrate pKJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2019Article
- Nuclear Resonance Vibrational Spectroscopy Definition of OJournal of the American Chemical Society · 2018Article
- Probing Hydrogen Bonding Interactions to Iron-Oxido/Hydroxido Units byAngewandte Chemie (International ed. in English) · 2018Article
- Diiron monooxygenases in natural product biosynthesis.Natural product reports · 2018Review
- On the Structure and Reaction Mechanism of Human Acireductone Dioxygenase.Chemistry (Weinheim an der Bergstrasse, Germany) · 2018Article
- Manganese and Cobalt in the Nonheme-Metal-Binding Site of a Biosynthetic Model of Heme-Copper Oxidase Superfamily Confer Oxidase Activity through Redox-Inactive Mechanism.Journal of the American Chemical Society · 2017Article
- Oxygen activation by mononuclear Mn, Co, and Ni centers in biology and synthetic complexes.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2017Review
- Dioxygen activation by nonheme iron enzymes with the 2-His-1-carboxylate facial triad that generate high-valent oxoiron oxidants.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2017Review
- 3,4-Dihydroxyphenylacetate 2,3-dioxygenase from Pseudomonas aeruginosa: An Fe(II)-containing enzyme with fast turnover.PloS one · 2017Article
- An iron-oxygen intermediate formed during the catalytic cycle of cysteine dioxygenase.Chemical communications (Cambridge, England) · 2016Article
- Enzyme Substrate Complex of the H200C Variant of Homoprotocatechuate 2,3-Dioxygenase: Mössbauer and Computational Studies.Inorganic chemistry · 2016Article
- Catalytic strategies of the non-heme iron dependent oxygenases and their roles in plant biology.Current opinion in chemical biology · 2016Review
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Funding
Abstract
Extradiol-cleaving catechol dioxygenases function by binding both the organic substrate and O2 at a divalent metal center in the active site. They have proven to be a particularly versatile group of enzymes with which to study the O2 activation process. Here, recent studies of homoprotocatechuate 2,3-dioxygenase are summarized, showing how nature can utilize the enzyme structure and the properties of the metal and the substrate to select among many possible chemical paths to achieve both specificity and efficiency. Possible intermediates in the mechanism have been trapped by swapping active-site metals, introducing active-site amino acid substituted variants, and using substrates with different electron-donating capacities. Although each of these intermediates could form part of a viable reaction pathway, kinetic measurements significantly limit the likely candidates. Structural, kinetic, spectroscopic, and computational analyses of the various intermediates shed light on how catalytic efficiency can be achieved.
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