ArticleJournal of molecular evolution2014
The evolution of reproduction-related NLRP genes.
Article in Journal of molecular evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
- Conservation of NLRP3 Inflammasome Pathway in Monotremes and Large-Scale Restructuring of the Caspase-1 Gene Cluster Region in Mammals.Journal of molecular evolution · 2026Article
- Advances in the genetic etiology of female infertility.Journal of assisted reproduction and genetics · 2024Review
- HLA-C expression in extravillous trophoblasts is determined by an ELF3-NLRP2/NLRP7 regulatory axis.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- NLRP7 participates in the human subcortical maternal complex and its variants cause female infertility characterized by early embryo arrest.Journal of molecular medicine (Berlin, Germany) · 2023Article
- NLRP7 Enhances Choriocarcinoma Cell Survival and Camouflage in an Inflammasome Independent Pathway.Cells · 2023Article
- Modulation of Nod-like Receptor Expression in the Thymus during Early Pregnancy in Ewes.Vaccines · 2022Article
- Review
- Syndromic Disorders Caused by Disturbed Human ImprintingJournal of clinical research in pediatric endocrinology · 2020Review
- NOD-like Receptors in the Eye: Uncovering Its Role in Diabetic Retinopathy.International journal of molecular sciences · 2020Review
- Systematic analysis of genetic variants in cancer-testis genes identified two novel lung cancer susceptibility loci in Chinese population.Journal of Cancer · 2020Article
- Article
- NLRP7 is expressed in the ovine ovary and associated with in vitro pre-implantation embryo development.Reproduction (Cambridge, England) · 2019Article
- Copy number variants implicate cardiac function and development pathways in earthquake-induced stress cardiomyopathy.Scientific reports · 2018Article
- Absence of Maternal Methylation in Biparental Hydatidiform Moles from Women with NLRP7 Maternal-Effect Mutations Reveals Widespread Placenta-Specific Imprinting.PLoS genetics · 2015Article
- Exome sequencing of lymphomas from three dog breeds reveals somatic mutation patterns reflecting genetic background.Genome research · 2015Article
- Intrinsic flexibility of NLRP pyrin domains is a key factor in their conformational dynamics, fold stability, and dimerization.Protein science : a publication of the Protein Society · 2015Article
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
NLRP proteins are important components of inflammasomes with a major role in innate immunity. A subset of NLRP genes, with unknown functions, are expressed in oocytes and early embryos. Mutations of Nlrp5 in mice are associated with maternal-effect embryonic lethality and mutations of NLRP7 in women are associated with conception of biparental complete hydatidiform moles (biCHMs), suggesting perturbed processes of genomic imprinting. Recessive mutations on NLRP2/7 in humans are associated with reproductive disorders and appear to be induced by a demethylation of the maternal pronucleus. In this study, we find that radiation of NLRP genes occurred before the common ancestor of Afrotheria and Boreoeutheria, with the clade of oocyte-expressed genes originating before the divergence of marsupial and eutherian mammals. There have been multiple independent duplications of NLRP2 genes one of which produced the NLRP7 gene associated with biCHMs.
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