Evidence map›Paper›PMID 24615132›Full record

Trial reportThe American journal of tropical medicine and hygiene2014

Impact of mass azithromycin distribution on malaria parasitemia during the low-transmission season in Niger: a cluster-randomized trial.

Bruce D Gaynor, Abdou Amza, Boubacar Kadri, Baido Nassirou, Ousmane Lawan, Laouali Maman, Nicole E Stoller, Sun N Yu, Stephanie A Chin, Sheila K West and 5 more

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of tropical medicine and hygiene, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.

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  12. Anthropometry and Malaria among Children in Niger: A Cross-Sectional Study.The American journal of tropical medicine and hygiene · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 3 countries.

Bruce D GaynorF.I. Proctor Foundation, Department of Ophthalmology, Department of Epidemiology and Biostatistics, Institute for Global Health, Department of Medicine, University of California, San Francisco, California; Programme National de Lutte Contre la Cecité Niamey, Niger; Zinder Hospital, Zinder, Niger; Dana Center for Preventive Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland; Clinical Research Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Abdou Amza
Boubacar Kadri
Baido Nassirou
Ousmane Lawan
Laouali Maman
Nicole E Stoller
Sun N Yu
Stephanie A Chin
Sheila K West
Robin L Bailey
Philip J Rosenthal
Jeremy D Keenan
Travis C Porco
Thomas M Lietman
University of California, San Francisco · USAbdou Moumouni University · NEUniversité de Zinder · NELondon School of Hygiene & Tropical Medicine · GBUniversity of London · GB

Funding

CTSA: K12 COMPONENTKL2RR024130 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$19.3M
Clinical and Transtional Science InstituteKL2TR000143 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$11.9M
Primary and Secondary Effects of Mass Antibiotic Distributions for TrachomaK23EY019881 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GAYNOR, BRUCE D. · 2010 to 2014
$1.1M
NCATS NIH HHS KL2 TR000143NCRR NIH HHS KL2 RR024130NEI NIH HHS K23 EY019881PHS HHS K23 EYO19881-01
6 · The paper itself

Abstract

We assessed the effect of mass azithromycin treatment on malaria parasitemia in a trachoma trial in Niger. Twenty-four study communities received treatment during the wet, high-transmission season. Twelve of the 24 communities were randomized to receive an additional treatment during the dry, low-transmission season. Outcome measurements were conducted at the community-level in children < 1-72 months of age in May-June 2011. Parasitemia was higher in the 12 once-treated communities (29.8%, 95% confidence interval [CI] = 21.5-40.0%) than in the 12 twice-treated communities (19.5%, 95% CI = 13.0-26.5%, P = 0.03). Parasite density was higher in once-treated communities (354 parasites/μL, 95% CI = 117-528 parasites/μL) than in twice-treated communities (74 parasites/μL, 95% CI = 41-202 parasites/μL, P = 0.03). Mass distribution of azithromycin reduced malaria parasitemia 4-5 months after the intervention. The results suggest that drugs with antimalaria activity can have long-lasting impacts on malaria during periods of low transmission.

Indexed as

AzithromycinChildChild, PreschoolCluster AnalysisDNA, ProtozoanFemaleHumansInfantLogistic ModelsMalariaMaleNigerParasitemiaPrevalenceSeasonsTreatment OutcomeAzithromycinDNA, Protozoan

Identifiers

PMID24615132
PMCPMC4015576
OpenAlexW2132553165

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.