ArticleThe American journal of tropical medicine and hygiene2014
G6PD A- deficiency and severe malaria in The Gambia: heterozygote advantage and possible homozygote disadvantage.
Article in The American journal of tropical medicine and hygiene, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- A multiscale approach to understanding the shared blue-orange flower color polymorphism in two Lysimachia species.BMC plant biology · 2024Article
- Potentially pathogenic and pathogenic G6PD variants.American journal of human genetics · 2023Article
- Effect of iron fortification on anaemia and risk of malaria among Ghanaian pre-school children with haemoglobinopathies and different ABO blood groups.BMC nutrition · 2023Article
- Duffy blood system and G6PD genetic variants in vivax malaria patients from Manaus, Amazonas, Brazil.Malaria journal · 2022Article
- Global perspectives onFrontiers in pharmacology · 2022Review
- Past and current biological factors affecting malaria in the low transmission setting of Botswana: A review.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2020Review
- Assessment of protective relationship of G6PD and other lifestyle factors with Malaria: A case-control study of medical professionals from a teaching medical institute, Gujarat.Journal of family medicine and primary care · 2020Article
- Prevalence and distribution of G6PD deficiency: implication for the use of primaquine in malaria treatment in Ethiopia.Malaria journal · 2019Article
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- CCR5del32 genotype in human enteroviral cardiomyopathy leads to spontaneous virus clearance and improved outcome compared to wildtype CCR5.Journal of translational medicine · 2018Article
- The role of the red blood cell in host defence against falciparum malaria: an expanding repertoire of evolutionary alterations.British journal of haematology · 2017Review
- Ankyrin-1 Gene Exhibits Allelic Heterogeneity in Conferring Protection Against Malaria.G3 (Bethesda, Md.) · 2017Article
- Assessing risk for Mendelian disorders in a Bronx population.Molecular genetics & genomic medicine · 2017Article
- Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia.eLife · 2017Article
- Heterogeneous alleles comprising G6PD deficiency trait in West Africa exert contrasting effects on two major clinical presentations of severe malaria.Malaria journal · 2016Article
- Molecular Heterogeneity of Glucose-6-Phosphate Dehydrogenase Deficiency in Burkina Faso: G-6-PD Betica Selma and Santamaria in People with Symptomatic Malaria in Ouagadougou.Mediterranean journal of hematology and infectious diseases · 2016Article
- Glucose-6-phosphate dehydrogenase deficiency and the risk of malaria and other diseases in children in Kenya: a case-control and a cohort study.The Lancet. Haematology · 2015Article
- African glucose-6-phosphate dehydrogenase alleles associated with protection from severe malaria in heterozygous females in Tanzania.PLoS genetics · 2015Article
- Glucose-6-phosphate dehydrogenase polymorphisms and susceptibility to mild malaria in Dogon and Fulani, Mali.Malaria journal · 2014Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 3 countries.
Funding
Abstract
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is frequent in Africa, because it confers resistance to Plasmodium falciparum malaria; however, the nature of the protection and the genotypes associated with it have been controversial. In 1972, Bienzle and others described protection from malaria in West African females heterozygous for G6PD A-. They determined that G6PD A- heterozygotes had lower parasite counts than A- homozygotes, hemizygous males, and normal individuals. However, other studies have reached different conclusions about the protective genotypes. DNA samples from 135 children with severe malaria and 146 children with mild malaria from The Gambia were genotyped for the G6PD A- mutation that is most frequent among Gambians (G6PD 968 T->C); there was a marked deficiency of heterozygotes and an excess of homozygotes with severe malaria, producing a strong deviation from Hardy-Weinberg equilibrium. Our results support the protective effect in G6PD A- heterozygous females and suggest that homozygotes might be more susceptible to severe malaria attacks.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.