Evidence map›Paper›PMID 24615014›Full record

ArticleMolecular and cellular biology2014

Mitofusin 1 is negatively regulated by microRNA 140 in cardiomyocyte apoptosis.

Jincheng Li, Yuzhen Li, Jianqin Jiao, Jianxun Wang, Yanrui Li, Danian Qin, Peifeng Li

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 2 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 2 syntheses or guidelines pooled it, 137 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Guidelines for mitochondrial RNA analysis.Molecular therapy. Nucleic acids · 2024
    Review
  12. Article
  13. Review
  14. A detailed review of pharmacology of MFN1 (mitofusion-1)-mediated mitochondrial dynamics: Implications for cellular health and diseases.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024
    Review
  15. Article
  16. Review
  17. Review
  18. Non-coding RNAs regulating mitochondrial function in cardiovascular diseases.Journal of molecular medicine (Berlin, Germany) · 2023
    Review
  19. Review
  20. Effect of troxerutin on the expression of genes regulating mitochondrial biogenesis and microRNA-140 in doxorubicin-induced testicular toxicity.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2023
    Article

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Jincheng LiDepartment of Physiology, Shantou University School of Medicine, Shantou, China.
Yuzhen Li
Jianqin Jiao
Jianxun Wang
Yanrui Li
Danian Qin
Peifeng Li
Institute of Zoology · CNShantou University · CNChinese Academy of Sciences · CNChinese PLA General Hospital · CNNebraska Medical Center · US

Funding

Role of mitochondria in cardiac ischemiaR01HL102202 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LI, PEIFENG · 2011 to 2015
$1.5M
NHLBI NIH HHS R01 HL102202
6 · The paper itself

Abstract

MicroRNAs (miRNAs) are a class of small noncoding RNAs that mediate posttranscriptional gene silencing. Mitochondrial fission participates in the induction of apoptosis. It remains largely unknown whether miRNAs can regulate mitochondrial fission. Reactive oxygen species and doxorubicin could induce mitochondrial fission and apoptosis in cardiomyocytes. Concomitantly, mitofusin 1 (Mfn1) was downregulated, whereas miRNA 140 (miR-140) was upregulated upon apoptotic stimulation. We investigated whether Mfn1 and miR-140 play a functional role in mitochondrial fission and apoptosis. Ectopic expression of Mfn1 attenuated mitochondrial fission and apoptosis. Knockdown of miR-140 inhibited mitochondrial fission. Our results further revealed that knockdown of miR-140 was able to reduce myocardial infarct sizes in an animal model. We observed that miR-140 could suppress the expression of Mfn1, and it exerted its effect on mitochondrial fission and apoptosis through targeting Mfn1. Our data revealed that mitochondrial fission occurs in cardiomyocytes and can be counteracted by Mfn1. However, the function of Mfn1 is negatively regulated by miR-140. Our present work suggests that Mfn1 and miR-140 are integrated into the program of cardiomyocyte apoptosis.

Indexed as

ApoptosisRNA Interference3' Untranslated RegionsAnimalsBase SequenceBinding SitesCells, CulturedEndodeoxyribonucleasesMembrane ProteinsMicroRNAsMitochondria, HeartMitochondrial DynamicsMitochondrial ProteinsMyocardial InfarctionMyocytes, CardiacRats3' Untranslated RegionsEndodeoxyribonucleasesendonuclease GMembrane ProteinsMfn1 protein, ratMicroRNAsMIRN140 microRNA, ratMitochondrial Proteins

Identifiers

PMID24615014
PMCPMC4019028
OpenAlexW2135850991

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.