ArticlePloS one2014
Differential white matter connectivity in early mild cognitive impairment according to CSF biomarkers.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Discriminating VCID subgroups: A diffusion MRI multi-model fusion approach.Journal of neuroscience methods · 2020Review
- Cognitively supernormal older adults maintain a unique structural connectome that is resistant to Alzheimer's pathology.NeuroImage. Clinical · 2020Article
- Relationships Between Diffusion Tensor Imaging and Cerebrospinal Fluid Metrics in Early Stages of the Alzheimer's Disease Continuum.Journal of Alzheimer's disease : JAD · 2019Review
- Neuroimaging in aging and neurologic diseases.Handbook of clinical neurology · 2019Review
- Tract-based analysis of white matter degeneration in Alzheimer's disease.Neuroscience · 2015Article
- Diffusion tensor imaging in Alzheimer's disease: insights into the limbic-diencephalic network and methodological considerations.Frontiers in aging neuroscience · 2014Review
- Multimodal magnetic resonance imaging study of treatment-naïve adults with attention-deficit/hyperactivity disorder.PloS one · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Mild cognitive impairment (MCI) is a heterogeneous group and certain MCI subsets eventually convert to dementia. Cerebrospinal fluid (CSF) biomarkers are known to predict this conversion. We sought evidence for the differences in white matter connectivity between early amnestic MCI (EMCI) subgroups according to a CSF phosphorylated tau181p/amyloid beta1-42 ratio of 0.10. From the Alzheimer's Disease Neuroimaging Initiative database, 16 high-ratio, 25 low-ratio EMCI patients, and 20 normal controls with diffusion tensor images and CSF profiles were included. Compared to the high-ratio group, radial diffusivity significantly increased in both sides of the corpus callosum and the superior and inferior longitudinal fasciculus in the low-ratio group. In widespread white matter skeleton regions, the low-ratio group showed significantly increased mean, axial, and radial diffusivity compared to normal controls. However, the high-ratio group showed no differences when compared to the normal group. In conclusion, our study revealed that there were significant differences in white matter connectivity between EMCI subgroups according to CSF phosphorylated tau181p/amyloid beta1-42 ratios.
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