ArticlePloS one2014
Characteristics of hospitalized acute Q fever patients during a large epidemic, The Netherlands.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 41 citations in OpenAlex.
- Omadacycline in the treatment of severe Q fever pneumonia during an influenza epidemic: a case report with literature review.Frontiers in medicine · 2025Article
- Serological Prevalence of and Risk Factors forInternational journal of environmental research and public health · 2022Article
- Epidemiological investigation and physician awareness regarding the diagnosis and management of Q fever in South Korea, 2011 to 2017.PLoS neglected tropical diseases · 2021Article
- Proteomic Identification of Coxiella burnetii Effector Proteins Targeted to the Host Cell Mitochondria During Infection.Molecular & cellular proteomics : MCP · 2021Article
- Long-term impact of a Q-fever outbreak: An evaluation of health symptoms, health-related quality of life, participation and health care satisfaction after ten years.Journal of psychosomatic research · 2020Article
- Serum C-reactive protein and procalcitonin values in acute Q fever, scrub typhus, and murine typhus.BMC infectious diseases · 2020Article
- Seroprevalence and risk factors of Coxiella burnetii infection in cattle in northeast Algeria.Tropical animal health and production · 2020Article
- A Novel Marmoset (Frontiers in cellular and infection microbiology · 2020Article
- Clinical characteristics of acute Q fever patients in South Korea and time from symptom onset to serologic diagnosis.BMC infectious diseases · 2019Article
- Article
- Q-vaxcelerate: A distributed development approach for a new Coxiella burnetii vaccine.Human vaccines & immunotherapeutics · 2017Review
- From Q Fever to Coxiella burnetii Infection: a Paradigm Change.Clinical microbiology reviews · 2017Review
- Community-acquired pneumonia related to intracellular pathogens.Intensive care medicine · 2016Review
- Estimation of acute and chronic Q fever incidence in children during a three-year outbreak in the Netherlands and a comparison with international literature.BMC research notes · 2015Article
- Differentiation of Acute Q Fever from Other Infections in Patients Presenting to Hospitals, the NetherlandsEmerging infectious diseases · 2015Article
- Observational
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFrom 2007 to 2009, The Netherlands experienced a major Q fever epidemic, with higher hospitalization rates than the 2-5% reported in the literature for acute Q fever pneumonia and hepatitis. We describe epidemiological and clinical features of hospitalized acute Q fever patients and compared patients presenting with Q fever pneumonia with patients admitted for other forms of community-acquired pneumonia (CAP). We also examined whether proximity to infected ruminant farms was a risk factor for hospitalization.
methodsA retrospective cohort study was conducted for all patients diagnosed and hospitalized with acute Q fever between 2007 and 2009 in one general hospital situated in the high incidence area in the south of The Netherlands. Pneumonia severity scores (PSI and CURB-65) of acute Q fever pneumonia patients (defined as infiltrate on a chest x-ray) were compared with data from CAP patients. Hepatitis was defined as a >twofold the reference value for alanine aminotransferase and for bilirubin.
resultsAmong the 183 hospitalized acute Q fever patients, 86.0% had pneumonia. Elevated liver enzymes (alanine aminotransferase) were found in 32.3% of patients, although hepatitis was not observed in any of them. The most frequent clinical signs upon presentation were fever, cough and dyspnoea. The median duration of admission was five days. Acute Q fever pneumonia patients were younger, had less co-morbidity, and lower PSI and CURB-65 scores than other CAP patients. Anecdotal information from attending physicians suggests that some patients were admitted because of severe subjective dyspnoea, which was not included in the scoring systems. Proximity to an infected ruminant farm was not associated with hospitalization.
conclusionHospitalized Dutch acute Q fever patients mostly presented with fever and pneumonia. Patients with acute Q fever pneumonia were hospitalized despite low PSI and CURB-65 scores, presumably because subjective dyspnoea was not included in the scoring systems.
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