Evidence map›Paper›PMID 24614497›Full record

ArticleMolecular psychiatry2015

A genome-wide linkage and association study of musical aptitude identifies loci containing genes related to inner ear development and neurocognitive functions.

J Oikkonen, Y Huang, P Onkamo, L Ukkola-Vuoti, P Raijas, K Karma, V J Vieland, I Järvelä

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.

  1. Pooled it
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  4. Knockout ofBiomedicines · 2024
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  15. Human Genomics and the Biocultural Origin of Music.International journal of molecular sciences · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

J Oikkonen1] Department of Medical Genetics, University of Helsinki, Helsinki, Finland [2] Department of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.
Y HuangThe Research Institute at Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA.
P OnkamoDepartment of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.
L Ukkola-VuotiDepartment of Medical Genetics, University of Helsinki, Helsinki, Finland.
P RaijasSibelius Academy, University of the Arts Helsinki, Helsinki, Finland.
K KarmaSibelius Academy, University of the Arts Helsinki, Helsinki, Finland.
V J VielandThe Research Institute at Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA.
I JärveläDepartment of Medical Genetics, University of Helsinki, Helsinki, Finland.
University of Helsinki · FIUniversity of the Arts Helsinki · FINationwide Children's Hospital · USThe Ohio State University · US

Funding

NIMH Center Repository Supporting Stem Cell ResearchU24MH068457 · NIMH · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI BRZUSTOWICZ, LINDA M, KNOWLES, JAMES A · 2003 to 2024
$213.8M
Combining epidemiologic designs to model genetic risks for psychiatric disordersR01MH086117 · NIMH · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI VIELAND, VERONICA J. · 2009 to 2011
$2.7M
Medical Research Council G0900747 91070NIMH NIH HHS R01 MH086117NIMH NIH HHS U24 MH068457Wellcome TrustWellcome Trust 090532/Z/09/Z
6 · The paper itself

Abstract

Humans have developed the perception, production and processing of sounds into the art of music. A genetic contribution to these skills of musical aptitude has long been suggested. We performed a genome-wide scan in 76 pedigrees (767 individuals) characterized for the ability to discriminate pitch (SP), duration (ST) and sound patterns (KMT), which are primary capacities for music perception. Using the Bayesian linkage and association approach implemented in program package KELVIN, especially designed for complex pedigrees, several single nucleotide polymorphisms (SNPs) near genes affecting the functions of the auditory pathway and neurocognitive processes were identified. The strongest association was found at 3q21.3 (rs9854612) with combined SP, ST and KMT test scores (COMB). This region is located a few dozen kilobases upstream of the GATA binding protein 2 (GATA2) gene. GATA2 regulates the development of cochlear hair cells and the inferior colliculus (IC), which are important in tonotopic mapping. The highest probability of linkage was obtained for phenotype SP at 4p14, located next to the region harboring the protocadherin 7 gene, PCDH7. Two SNPs rs13146789 and rs13109270 of PCDH7 showed strong association. PCDH7 has been suggested to play a role in cochlear and amygdaloid complexes. Functional class analysis showed that inner ear and schizophrenia-related genes were enriched inside the linked regions. This study is the first to show the importance of auditory pathway genes in musical aptitude.

Indexed as

Genetic LinkageMusicAdolescentAdultAgedAged, 80 and overAptitudeAuditory PerceptionBayes TheoremChildCognitionEar, InnerFamily HealthFemaleGenetic Association StudiesGenotype

Identifiers

PMID24614497
PMCPMC4259854
OpenAlexW1984598220

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.