ArticleAntimicrobial agents and chemotherapy2014
Potential of Ergosterol synthesis inhibitors to cause resistance or cross-resistance in Trichophyton rubrum.
Article in Antimicrobial agents and chemotherapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 58 citations in OpenAlex.
- Emergence of resistant dermatophytosis caused byMedical mycology case reports · 2025Article
- Mechanisms of resistance against allylamine and azole antifungals in Trichophyton: A renewed call for innovative molecular diagnostics in susceptibility testing.PLoS pathogens · 2025Review
- Resistance Profile, Terbinafine Resistance Screening and MALDI-TOF MS Identification of the Emerging Pathogen Trichophyton indotineae.Mycopathologia · 2024Article
- Comparison of in vitro activities of newer triazoles and classic antifungal agents against dermatophyte species isolated from Iranian University Hospitals: a multi-central study.Annals of clinical microbiology and antimicrobials · 2023Article
- The in vitro Activity of Echinocandins Against ClinicalInfection and drug resistance · 2023Article
- Molecular Epidemiology and Antifungal Susceptibility ofJournal of fungi (Basel, Switzerland) · 2021Article
- Article
- Regional Differences in Antifungal Susceptibility of the Prevalent Dermatophyte Trichophyton rubrum.Mycopathologia · 2021Article
- Lactobacillus plantarum strain HT-W104-B1: potential bacterium isolated from Malaysian fermented foods for control of the dermatophyte Trichophyton rubrum.World journal of microbiology & biotechnology · 2021Article
- Preliminary Study on Antifungal Mechanism of Aqueous Extract ofFrontiers in microbiology · 2021Article
- The Sensitivity Modifying Activity of Nerolidol and α-Bisabolol AgainstIndian journal of microbiology · 2020Article
- Ciclopirox Hydroxypropyl Chitosan (HPCH) Nail Lacquer: A Review of Its Use in Onychomycosis.Dermatology and therapy · 2020Review
- Whole-genome resequencing of Trichophyton rubrum provides insights into population differentiation and drug resistance.Mycopathologia · 2020Article
- Ciclopirox and Efinaconazole Transungual Permeation, Antifungal Activity, and Proficiency To Induce Resistance in Trichophyton rubrum.Antimicrobial agents and chemotherapy · 2019Article
- Dermatophyte Resistance to Antifungal Drugs: Mechanisms and Prospectus.Frontiers in microbiology · 2018Review
- Epidemiological status of dermatophytosis in Guilan, north of Iran.Current medical mycology · 2017Article
- Ciclopirox 8% HPCH Nail Lacquer in the Treatment of Mild-to-Moderate Onychomycosis: A Randomized, Double-Blind Amorolfine Controlled Study Using a Blinded Evaluator.Skin appendage disorders · 2016Article
- Article
- Antifungal Drug Susceptibility Testing of Dermatophytes: Laboratory Findings to Clinical Implications.Indian dermatology online journalArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Superficial mycoses caused by Trichophyton rubrum are among the most common infections worldwide. T. rubrum infections are difficult to treat and are often associated with recurrences after interruption of the antifungal therapy. Nevertheless, reports on T. rubrum resistance to commonly used antifungal drugs are rare. In this study, we compared the in vitro resistance frequencies and development of resistance to terbinafine, itraconazole, amorolfine, and ciclopirox in T. rubrum. Results demonstrated that naturally occurring mutants were isolated at a frequency of 10(-7) for itraconazole and 10(-9) for terbinafine and amorolfine. To mimic conditions of body sites in which low drug levels are reached during therapy, T. rubrum was propagated for 10 transfers in media containing subinhibitory drug concentrations. Resistance to itraconazole, terbinafine, and amorolfine emerged at a higher frequency than was seen with spontaneous mutation. Itraconazole-resistant mutants also showed decreased susceptibility to amorolfine as well as to terbinafine, and amorolfine-resistant mutants were also less susceptible to terbinafine. No mutant resistant to ciclopirox was isolated, suggesting no propensity of T. rubrum to develop resistance to this drug. How different drug mechanisms of action can influence the onset of resistance is discussed.
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