ArticlePloS one2014
Measuring virgin female aggression in the female intruder test (FIT): effects of oxytocin, estrous cycle, and anxiety.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 65 citations in OpenAlex.
- Oxytocin increases the likeability of physically formidable men.Social cognitive and affective neuroscience · 2015Trial
- Ventromedial hypothalamus (VMHvl) nNOS neurons regulate social behaviors in a sex-specific manner.Communications biology · 2025Article
- Intranasal oxytocin interacts with testosterone reactivity to modulate parochial altruism.Communications psychology · 2024Article
- Detection, processing and reinforcement of social cues: regulation by the oxytocin system.Nature reviews. Neuroscience · 2023Review
- Monitoring oxytocin signaling in the brain: More than a love story.Comprehensive psychoneuroendocrinology · 2023Review
- Isoallopregnanolone Inhibits Estrus Cycle-Dependent Aggressive Behavior.Biomolecules · 2023Article
- Activation of glucagon-like peptide-1 receptors reduces the acquisition of aggression-like behaviors in male mice.Translational psychiatry · 2022Article
- Tetratricopeptide repeat domain 9A knockout induces social anxiety and impairs offense behaviors in female mice.Iranian journal of basic medical sciences · 2022Article
- Modelling sexual violence in male rats: the sexual aggression test (SxAT).Translational psychiatry · 2022Article
- Neuroendocrine regulation of female aggression.Frontiers in endocrinology · 2022Review
- Vocalization during agonistic encounter in Mongolian gerbils: Impact of sexual experience.PloS one · 2022Article
- Synthetic Oxytocin and Vasopressin Act Within the Central Amygdala to Exacerbate Aggression in Female Wistar Rats.Frontiers in neuroscience · 2022Article
- The Nanotheranostic Researcher's Guide for Use of Animal Models of Traumatic Brain Injury.Journal of nanotheranostics · 2021Article
- Oxytocin and vasopressin within the ventral and dorsal lateral septum modulate aggression in female rats.Nature communications · 2021Article
- Dynamic regulation of oxytocin neuronal circuits in the sequential processes of prosocial behavior in rodent models.Current research in neurobiology · 2021Review
- Article
- Social approach and social vigilance are differentially regulated by oxytocin receptors in the nucleus accumbens.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Fighting Females: Neural and Behavioral Consequences of Social Defeat Stress in Female Mice.Biological psychiatry · 2019Article
- Towards a neurobiology of female aggression.Neuropharmacology · 2019Review
- Social hierarchy position in female mice is associated with plasma corticosterone levels and hypothalamic gene expression.Scientific reports · 2019Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The costs of violence and aggression in our society have stimulated the scientific search for the predictors and causes of aggression. The majority of studies have focused on males, which are considered to be more aggressive than females in most species. However, rates of offensive behavior in girls and young women are considerable and are currently rising in Western society. The extrapolation of scientific results from males to young, non-maternal females is a priori limited, based on the profound sex differences in brain areas and functioning of neurotransmitters involved in aggression. Therefore, we established a paradigm to assess aggressive behavior in young virgin female rats, i.e. the female intruder test (FIT). We found that approximately 40% of un-manipulated adult (10-11 weeks old) female Wistar rats attack an intruder female during the FIT, independent of their estrous phase or that of their intruder. In addition, adolescent (7-8 weeks old) female rats selected for high anxiety behavior (HABs) displayed significantly more aggression than non-selected (NAB) or low-anxiety (LAB) rats. Intracerebroventricular infusion of oxytocin (OXT, 0.1 µg/5 µl) inhibited aggressive behavior in adult NAB and LAB, but not HAB females. Adolescent NAB rats that had been aggressive towards their intruder showed increased pERK immunoreactivity (IR) in the hypothalamic attack area and reduced pERK-IR in OXT neurons in the paraventricular hypothalamic nucleus compared to non-aggressive NAB rats. Taken together, aggressive behavior in young virgin female rats is partly dependent on trait anxiety, and appears to be under considerable OXT control.
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