ArticleThe Journal of reproduction and development2014
Suppression of progesterone-enhanced hyperactivation in hamster spermatozoa by γ-aminobutyric acid.
Article in The Journal of reproduction and development, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed, 25 citations in OpenAlex.
- Regulation of spermatozoal capacitation by serotonin.The Journal of reproduction and development · 2026Review
- Interactions among progesterone, estradiol, and γ-aminobutyric acid in rat spermatozoal hyperactivation.The Journal of reproduction and development · 2026Article
- Tryptophan promotes sperm hyperactivation in hamsters via 5-hydroxytryptamine biosynthesis within sperm.The Journal of reproduction and development · 2025Article
- Influences of 5-hydroxytriptamine on sperm hyperactivation and in vitro fertility in rats.The Journal of reproduction and development · 2025Article
- Boar Sperm Motility Assessment Using Computer-Assisted Sperm Analysis: Current Practices, Limitations, and Methodological Challenges.Animals : an open access journal from MDPI · 2025Review
- Progesterone and estradiol regulate sperm hyperactivation and in vitro fertilization success in mice.The Journal of reproduction and development · 2024Article
- Plasma γ-Aminobutyric Acid (GABA) Concentrations in Lactating Holstein Cows during Thermoneutral and Heat Stress Conditions and Their Relationships with Circulating Glucose, Insulin and Progesterone Levels.Veterinary sciences · 2024Article
- Enhancement of rat spermatozoal hyperactivation by progesterone.The Journal of reproduction and development · 2023Article
- Progesterone increases the success of in vitro fertilization via enhanced sperm hyperactivation in mice.The Journal of reproduction and development · 2023Article
- Serotonergic signals enhanced hamster sperm hyperactivation.The Journal of reproduction and development · 2021Article
- High mRNA expression of GABA receptors in human sperm with oligoasthenoteratozoospermia and teratozoospermia and its association with sperm parameters and intracytoplasmic sperm injection outcomes.Clinical and experimental reproductive medicine · 2021Article
- Expression and Possible Role of Nicotinic Acetylcholine Receptor ε Subunit (AChRe) in Mouse Sperm.Biology · 2021Article
- Effects of 5-hydroxytryptamine on spermatozoal hyperactivation and in vitro fertilization in mice.The Journal of reproduction and development · 2019Article
- Capacitation of mouse sperm is modulated by gamma-aminobutyric acid (GABA) concentration.The Journal of reproduction and development · 2019Article
- Selection for female traits of high fertility affects male reproductive performance and alters the testicular transcriptional profile.BMC genomics · 2017Article
- γ-Aminobutyric acid suppresses enhancement of hamster sperm hyperactivation by 5-hydroxytryptamine.The Journal of reproduction and development · 2017Article
- Review
- Roles of the reproductive tract in modifications of the sperm membrane surface.The Journal of reproduction and development · 2016Review
- Non-genomic regulation and disruption of spermatozoal in vitro hyperactivation by oviductal hormones.The journal of physiological sciences : JPS · 2016Review
- Estrogen suppresses melatonin-enhanced hyperactivation of hamster spermatozoa.The Journal of reproduction and development · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been recently shown that mammalian spermatozoa were hyperactivated by steroids, amines and amino acids. In the present study, we investigated whether hyperactivation of hamster sperm is regulated by progesterone (P) and γ-aminobutyric acid (GABA). Although sperm hyperactivation was enhanced by P, GABA significantly suppressed P-enhanced hyperactivation in a dose-dependent manner. Suppression of P-enhanced hyperactivation by GABA was significantly inhibited by an antagonist of the GABAA receptor (bicuculline). Moreover, P bound to the sperm head, and this binding was decreased by GABA. Because the concentrations of GABA and P change in association with the estrous cycle, these results suggest that GABA and P competitively regulate the enhancement of hyperactivation through the GABAA receptor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.