ArticlePloS one2014
Strategies for using the sheep ovarian cortex as a model in reproductive medicine.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Living in a chemical cocktail: real-world mixture exposures and their impact on ovarian function.The Journal of reproduction and development · 2026Review
- Reproductive seasonality influences follicle dynamics and the ovarian extracellular matrix structural properties in ewes.Reproduction (Cambridge, England) · 2025Article
- Primordial Follicle Response to Two Methods of Ovarian Cortex Retrieval and Vitrification: A Pilot Study.Cureus · 2025Article
- Changes in surfactant protein A and D in ovine ovaries related to follicle development.Veterinary research communications · 2024Article
- Effects of different subcutaneous sites on heterotopic autotransplantation of canine ovarian tissue.Veterinary research communications · 2023Article
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- Development of sheep secondary follicles and preservation of aromatase and metalloproteinases 2 and 9 after vitrification and in vitro culture.Cell and tissue banking · 2022Article
- Preantral follicle population and distribution in the horse ovary.Reproduction & fertility · 2022Article
- Characterization of preantral follicle clustering and neighborhood patterns in the equine ovary.PloS one · 2022Article
- The challenge of ovarian tissue culture: 2D versus 3D culture.Journal of ovarian research · 2021Article
- Multispecies study: low-dose tributyltin impairs ovarian theca cell cholesterol homeostasis through the RXR pathway in five mammalian species including humans.Archives of toxicology · 2019Article
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- Multiplex gene editing via CRISPR/Cas9 exhibits desirable muscle hypertrophy without detectable off-target effects in sheep.Scientific reports · 2016Article
- Supplementation of transport and freezing media with anti-apoptotic drugs improves ovarian cortex survival.Journal of ovarian research · 2016Article
- The Mare Model to Study the Effects of Ovarian Dynamics on Preantral Follicle Features.PloS one · 2016Article
- Influence of mouse strain on ovarian tissue recovery after engraftment with angiogenic factor.Journal of ovarian research · 2015Article
- Isoform 165 of vascular endothelial growth factor in collagen matrix improves ovine cryopreserved ovarian tissue revascularisation after xenotransplantation in mice.Reproductive biology and endocrinology : RB&E · 2015Article
- Effects of neutral red assisted viability assessment on the cryotolerance of isolated bovine preantral follicles.Journal of assisted reproduction and genetics · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate and compare the distribution and density of primordial follicles within a whole sheep ovary and to gain insight into how to overcome the impact of natural follicular heterogeneity on the experimental results.
designHistological study.
settingAcademic research center. ANIMALS: Five- to nine-month-old ewes.
interventionsFreshly sampled whole sheep ovaries were collected and prepared for histological analysis. MAIN OUTCOME MEASURE(S): The follicular densities and distributions were determined for hematoxylin and eosin sections. A mathematical model was derived based on the follicle counts and Monte-Carlo simulations.
resultsHeterogeneous distributions and densities of primordial follicles were identified 1) for distinct areas of the same ovarian cortex, 2) between the ovaries of the same animal and 3) across different ewes. A mathematical model based on the analysis of 37,153 primordial follicles from 8 different ovaries facilitated the estimation of the number of cortical biopsies and sections that had to be analyzed to overcome such heterogeneity.
conclusionThe influence of physiological follicular heterogeneity on experimental and clinical results can be overcome when a definite number of cortical pieces and sections are taken into consideration.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.