ArticleJournal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer2013
Treatment modalities for T1N0 esophageal cancers: a comparative analysis of local therapy versus surgical resection.
Article in Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Prediction of lymph node metastasis in early esophageal cancer.World journal of gastrointestinal surgery · 2023Article
- Endoscopic therapy replaces surgery for clinical T1 oesophageal cancer in the Netherlands: a nationwide population-based study.Surgical endoscopy · 2023Article
- Role of Recurrent Laryngeal Nerve Lymph Node Dissection in Surgery of Early-Stage Esophageal Squamous Cell Carcinoma.Annals of surgical oncology · 2022Article
- The Least Nodal Disease Burden Defines the Minimum Number of Nodes Retrieved for Esophageal Squamous Cell Carcinoma.Frontiers in oncology · 2022Article
- Risk factors for distant metastasis and prognosis in stage T1 esophageal cancer: A population-based study.Frontiers in surgery · 2022Article
- Synchronous multiple primary malignancies of the esophagus, stomach, and jejunum: A case report.World journal of clinical cases · 2021Article
- The Influence of Different Treatment Strategies on the Long-Term Prognosis of T1 Stage Esophageal Cancer Patients.Frontiers in oncology · 2021Article
- ECCDIA: an interactive web tool for the comprehensive analysis of clinical and survival data of esophageal cancer patients.BMC cancer · 2020Article
- Development of a predictive nomogram for cause-specific mortality in surgically resected early-stage oesophageal cancer: a Surveillance, Epidemiology, and End Results (SEER) analysis.Journal of thoracic disease · 2020Article
- Comparative study of esophagectomy, endoscopic therapy, and radiotherapy for cT1N0M0 esophageal cancer in elderly patients: A SEER database analysis.Thoracic cancer · 2019Article
- Treatment disparities affect outcomes for patients with stage I esophageal cancer: a national cancer data base analysis.Journal of gastrointestinal oncology · 2019Article
- The renaissance of photodynamic therapy for early esophageal cancer: is it the time?Journal of thoracic disease · 2018Article
- Article
- A Surgical View of Photodynamic Therapy in Oncology: A Review.Surgery journal (New York, N.Y.) · 2015Review
- Esophageal cancer: staging system and guidelines for staging and treatment.Journal of thoracic disease · 2014Review
- Models for Predicting Early Death in Patients With Stage IV Esophageal Cancer: A Surveillance, Epidemiology, and End Results-Based Cohort Study.Cancer control : journal of the Moffitt Cancer CenterArticle
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundTo investigate the role of nonsurgical treatment for early-stage esophageal cancer, we compared the outcomes of local therapy to esophagectomy, using a large, national database.
methodsFive-year cancer-specific and overall survival (OS) of patients, with T1N0M0 squamous cell or adenocarcinoma of the mid or distal esophagus treated with either surgery or local therapy, with ablative and/or excision techniques, in the Surveillance Epidemiology and End Results cancer registry from 1998 to 2008, were compared using the Kaplan-Meier approach, and multivariable and propensity-score adjusted Cox proportional hazard, and competing risk models.
resultsOf 1458 patients with T1N0 esophageal cancer, 1204 (83%) had surgery and 254 (17%) had local therapy only. The use of local therapy increased significantly from 8.1% in 1998 to 24.1% in 2008 (p < 0.001). The 5-year OS after local excisional therapy and surgery was not significantly different (55.5% versus 64.1% respectively, p = 0.07), and 5-year cancer-specific survival (CSS) also did not differ (81.7% versus 75.8%, p = 0.10). However, after propensity-score adjustment, CSS was better for patients who underwent local therapy compared with those who underwent surgery (hazard ratio: 0.46, 95% confidence interval: 0.27-0.77, p = 0.003), whereas OS remained similar.
conclusionThe use of local therapy for T1N0 esophageal cancers increased significantly from 1998 to 2008. Compared with those treated with esophagectomy, patients treated with local therapy had similar OS but improved CSS, indicating a higher chance of dying from other causes. Further studies are needed to confirm the oncologic efficacy of local therapy when used in patients whose lifespans are not limited by conditions other than esophageal cancer.
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