Evidence map›Paper›PMID 24614194›Full record

ArticleLaboratory investigation; a journal of technical methods and pathology2014

Myeloid expression of angiotensin-converting enzyme facilitates myeloid maturation and inhibits the development of myeloid-derived suppressor cells.

Xiao Z Shen, Derick Okwan-Duodu, Wendell-Lamar Blackwell, Frank S Ong, Tea Janjulia, Ellen A Bernstein, Sebastien Fuchs, Serhan Alkan, Kenneth E Bernstein

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Laboratory investigation; a journal of technical methods and pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Exploring the Impact of ACE Inhibition in Immunity and Disease.Journal of the renin-angiotensin-aldosterone system : JRAAS · 2022
    Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Overexpression of myeloid angiotensin-converting enzyme (ACE) reduces atherosclerosis.Biochemical and biophysical research communications · 2019
    Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. The immunobiology of myeloid-derived suppressor cells in cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Xiao Z Shen1] Division of Immunology, Department of Biomedical Science, Cedars-Sinai Medical Center, Los Angeles, CA, USA [2] Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Derick Okwan-Duodu1] Division of Immunology, Department of Biomedical Science, Cedars-Sinai Medical Center, Los Angeles, CA, USA [2] School of Medicine, Emory University, Atlanta, GA, USA.
Wendell-Lamar BlackwellDivision of Immunology, Department of Biomedical Science, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Frank S OngDivision of Immunology, Department of Biomedical Science, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Tea JanjuliaDivision of Immunology, Department of Biomedical Science, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Ellen A BernsteinDivision of Immunology, Department of Biomedical Science, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Sebastien Fuchs1] Division of Immunology, Department of Biomedical Science, Cedars-Sinai Medical Center, Los Angeles, CA, USA [2] Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Serhan AlkanDepartment of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Kenneth E Bernstein1] Division of Immunology, Department of Biomedical Science, Cedars-Sinai Medical Center, Los Angeles, CA, USA [2] Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Cedars-Sinai Medical Center · US

Funding

RAS and InjuryR01HL110353 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI BERNSTEIN, KENNETH E · 2011 to 2015
$2.2M
Site-specific ACE Knockout Mice and Bleomycin-Induced Lung InjuryF32HL105036 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI ONG, FRANK SHIH-CHANG · 2011 to 2012
$103k
NHLBI NIH HHS F32 HL105036NHLBI NIH HHS R01 HL110353NHLBI NIH HHS R01 HL110353-26
6 · The paper itself

Abstract

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells which accumulate in cancer, infection and chronic inflammation. These cells suppress T-cell function and the immune response. Angiotensin-converting enzyme (ACE) is a peptidase that is now known to regulate aspects of myelopoiesis. Here, we show that ACE expression correlates with myeloid maturation in vitro. Forced ACE overexpression in monocytic cells reduces the generation of MDSCs. In vivo, mice with a genetic change resulting in myeloid cell ACE overexpression have reduced numbers of blood and splenic MDSCs in a tumor model and in a model of chronic inflammation induced by complete Freund's adjuvant. In contrast, ACE-null mice produce large numbers of MDSCs during chronic inflammation. Macrophages from mice with myeloid ACE overexpressing are more pro-inflammatory and have more tumor-killing activity than cells from wild-type mice. Thus, manipulating myeloid ACE activity can interfere with MDSC development and the maturation of myeloid cells.

Indexed as

MyelopoiesisAnimalsMelanoma, ExperimentalMiceMice, Inbred C57BLMyeloid Progenitor CellsPeptidyl-Dipeptidase APhenotypePeptidyl-Dipeptidase A

Identifiers

PMID24614194
PMCPMC4221240
OpenAlexW2022895634

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.