ArticlePloS one2014
Physical, cognitive and emotional factors contributing to quality of life, functional health and participation in community dwelling in chronic kidney disease.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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23 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Prevalence of cognitive impairment and its predictors among chronic kidney disease patients: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Associations of exercise habits with physical function and emergency dialysis start in patients with end-stage renal disease before dialysis initiation.Clinical and experimental nephrology · 2026Article
- Association between cognitive functioning and health-related quality of life and its mediation by depressive symptoms in older patients with kidney failure.Journal of nephrology · 2024Observational
- Health Care Resource Utilization and Related Costs of Patients With CKD From the United States: A Report From the DISCOVER CKD Retrospective Cohort.Kidney international reports · 2023Article
- Health-Related Quality of Life according to Renal Function: Results from a Nationwide Health Interview and Examination Survey.Kidney & blood pressure research · 2022Article
- Article
- Health-related quality of life in patients with non-communicable disease: study protocol of a cross-sectional survey.BMJ open · 2020Article
- Depression does not predict clinical outcome of Chinese peritoneal Dialysis patients after adjusting for the degree of frailty.BMC nephrology · 2020Observational
- The association of kidney function and cognitive decline in older patients at risk of cardiovascular disease: a longitudinal data analysis.BMC nephrology · 2020Article
- The association between volition and participation in adults with acquired disabilities: A scoping review.Hong Kong journal of occupational therapy : HKJOT · 2019Article
- Considering the utility of cognitive remediation therapy in chronic kidney disease.Clinical and experimental nephrology · 2019Article
- Assessment of physical functioning in the clinical care of the patient with advanced kidney disease.Seminars in dialysis · 2019Review
- Depressive Symptoms Associate With Race and All-Cause Mortality in Patients With CKD.Kidney international reports · 2019Article
- Cognitive load and emotional processing in psoriasis: a thermal imaging study.Experimental brain research · 2019Article
- Mobile Phone-Based Measures of Activity, Step Count, and Gait Speed: Results From a Study of Older Ambulatory Adults in a Naturalistic Setting.JMIR mHealth and uHealth · 2017Article
- Depression in Chronic Kidney Disease and End-Stage Renal Disease: Similarities and Differences in Diagnosis, Epidemiology, and Management.Kidney international reports · 2017Review
- Factors Responsible for Plasma β-Amyloid Accumulation in Chronic Kidney Disease.Molecular neurobiology · 2016Article
- Cognitive Performance Is Highly Stable over a 2-Year-Follow-Up in Chronic Kidney Disease Patients in a Dedicated Medical Environment.PloS one · 2016Article
- Observational
- Advance care planning: a qualitative study of dialysis patients and families.Clinical journal of the American Society of Nephrology : CJASN · 2015Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundQuality of life (QoL) impairment is a well-known consequence of chronic kidney disease (CKD). The factors influencing QoL and late life functional health are poorly examined.
methodsUsing questionnaires combined with neuropsychological examinations, we prospectively evaluated physical, cognitive, and emotional factors influencing QoL, functional health and participation in community dwelling in 119 patients with CKD stages 3-5 including hemodialysis (61.5±15.7years; 63% men) and 54 control patients of the same age without CKD but with similar cardiovascular risk profile.
resultsCompared with control patients, CKD patients showed impairment of the physical component of QoL and overall function, assessed by the SF-36 and LLFDI, whereas disability, assessed by LLFDI, was selectively impaired in CKD patients on hemodialysis. Multivariable linear regressions (forced entry) confirmed earlier findings that CKD stage (β = -0.24; p = 0.012) and depression (β = -0.30; p = 0.009) predicted the QoL physical component. Hitherto unknown, CKD stage (β = -0.23; p = 0.007), cognition (β = 0.20; p = 0.018), and depression (β = -0.51; <0.001) predicted disability assessed by the LLFDI, while age (β = -0.20; p = 0.023), male gender (B = 5.01; p = 0.004), CKD stage (β = -0.23; p = 0.005), stroke history (B = -9.00; p = 0.034), and depression (β = -0.41; p<0.001) predicted overall function. Interestingly, functional health deficits, cognitive disturbances, depression, and anxiety were evident almost only in CKD patients with coronary heart disease (found in 34.2% of CKD patients). The physical component of QoL and functional health decreased with age and depressive symptoms, and increased with cognitive abilities.
conclusionsIn CKD, QoL, functional health, and participation in community dwelling are influenced by physical, cognitive, and emotional factors, most prominently in coronary heart disease patients.
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