ArticlePloS one2014
Tumor vascularity and glucose metabolism correlated in adenocarcinoma, but not in squamous cell carcinoma of the lung.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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14 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Meta-analysis of segmentectomy versus lobectomy for radiologically pure solid or solid-dominant stage IA non-small cell lung cancer.Journal of cardiothoracic surgery · 2019Pooled it
- T1 mapping-based multi-parametric MRI for subtyping and differentiation grading of non-small cell lung cancer.Quantitative imaging in medicine and surgery · 2026Article
- Prediction of 2-[Cancers · 2023Article
- Diagnostic value of dynamicQuantitative imaging in medicine and surgery · 2023Article
- Role of Dynamic Contrast-Enhanced Magnetic Resonance Imaging Parameters and Extracellular Volume Fraction as Predictors of Lung Cancer Subtypes and Lymph Node Status in Non-Small-Cell Lung Cancer Patients.Journal of Cancer · 2023Article
- Relationships Between DCE-MRI, DWI, andMolecular imaging and radionuclide therapy · 2021Article
- Distribution and prognostic significance of gluconeogenesis and glycolysis in lung cancer.Molecular oncology · 2020Article
- [Progress in Survival Prognosis of Segmentectomy for Early-stage Non-small Cell Lung Cancer].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2020Review
- Article
- Outcomes and predictive factors for pathological node-positive in radiographically pure-solid, small-sized lung adenocarcinoma.General thoracic and cardiovascular surgery · 2019Article
- Free-breathing dynamic contrast-enhanced MRI for assessment of pulmonary lesions using golden-angle radial sparse parallel imaging.Journal of magnetic resonance imaging : JMRI · 2018Article
- Value of combining serum carcinoembryonic antigen and PET/CT in predictingJournal of thoracic disease · 2018Article
- Dynamic contrast-enhanced MRI versusChinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2018Article
- Assessment of Aggressiveness of Breast Cancer Using Simultaneous 18F-FDG-PET and DCE-MRI: Preliminary Observation.Clinical nuclear medicine · 2016Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesTo prospectively examine the relation between tumor vascularity and glucose metabolism in adenocarcinoma (AC) and squamous cell carcinoma(SCC) of the lung by using positron emission tomography/computed tomography (PET/CT) and dynamic contrast enhanced magnetic resonance imaging (DCE-MRI). MATERIALS AND
methodsForty-one consecutive patients with histologically confirmed untreated NSCLC underwent routine diagnostic work-up, including DCE-MRI and PET/CT. PET/CT images were used to derive glucose metabolism (SUVmax and SUVmean), and DCE-MRI images were used to derive tumor vascularity (Ktrans, Kep, Ve and iAUC). Any differences in the DCE-MRI and PET/CT estimations between the NSCLC subtypes were determined by the Wilcoxon rank sum test. Spearman's rank correlation coefficients were calculated between the DCE-MRI parameter values and the SUV.
resultsSUVmean and SUVmax in AC were significantly lower than in SCC, but Ktrans and Ve in AC were significantly higher than in SCC. Significant correlations between SUV and DCE-MRI parameters were observed for SUVmax and Ve (ρ = -0.357, P = 0.022), SUVmean and Ktrans (ρ = -0.341, P = 0.029), and SUVmean and iAUC (ρ = -0.374, P = 0.016 ) in total; for SUVmax and iAUC (ρ = -0.420, P = 0.037), SUVmean and Ktrans (ρ = -0.411, P = 0.041), SUVmean and Kep (ρ = -0.045, P = 0.026), and SUVmean and iAUC (ρ = -0.512, P = 0.009) in AC; However, for neither in SCC.
conclusionAC and SCC showed different patterns in both tumor vascularity and glucose metabolism. Tumor vascularity and glucose metabolism negatively correlated in AC, but not in SCC. These differences may underlie the heterogeneity in clinical aspect of NSCLC subtypes and have implications for their imaging profiling and monitor the treatment response.
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