Evidence map›Paper›PMID 24614122›Full record

ArticleJournal of pediatric gastroenterology and nutrition2014

Comparison of body composition assessment methods in pediatric intestinal failure.

Nilesh M Mehta, Bram Raphael, Ivan M Guteirrez, Nicolle Quinn, Paul D Mitchell, Heather J Litman, Tom Jaksic, Christopher P Duggan

Registry-linked trialAbstract readComparative Study
In one paragraph

Article in Journal of pediatric gastroenterology and nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02561819 (Measurement of Body Composition by Air Displacement Plethysmography in Pediatric Intestinal Failure Patients), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02561819 completednot on this mapstarted 2015, after this paper: background citation

Measurement of Body Composition by Air Displacement Plethysmography in Pediatric Intestinal Failure Patients

TypeobservationalSponsorChristopher DugganRan2015 to 2020Enrolled25ConditionsShort Bowel Syndrome
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Impact of Individualized Diet Intervention on Body Composition and Respiratory Variables in Children With Respiratory Insufficiency: A Pilot Intervention Study.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2015
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Nilesh M Mehta*Critical Care Medicine, Department of Anesthesiology, Perioperative and Pain Medicine †Division of Gastroenterology, Hepatology and Nutrition ‡Department of Surgery §Clinical and Translational Study Unit ||Clinical Research Center, Boston Children's Hospital and Harvard Medical School, Boston, MA.
Bram Raphael
Ivan M Guteirrez
Nicolle Quinn
Paul D Mitchell
Heather J Litman
Tom Jaksic
Christopher P Duggan
Boston Children's Hospital · USHarvard University · US

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CHRISTOPHER P DUGGAN · 1994 to 2026
$31.6M
WIRELESS CAPSULE ENDOSCOPY TO EVALUATE THE SMALL INTESTINE M01RR002172 · NCRR · CHILDREN'S HOSPITAL BOSTON · PI GRAND, RICHARD J · 1985 to 2008
$16.0M
Patient-oriented Research in Pediatric Diarrheal DiseasesK24HD058795 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI DUGGAN, CHRISTOPHER P · 2010 to 2014
$956k
NCRR NIH HHS M01 RR002172NCRR NIH HHS UL1 RR025758NCRR NIH HHS UL1RR025758NICHD NIH HHS K24 HD058795NICHD NIH HHS K24HD058795NIDDK NIH HHS P30 DK040561
6 · The paper itself

Abstract

objectivesThe aim of the study was to examine the agreement of multifrequency bioelectric impedance analysis (BIA) and anthropometry with reference methods for body composition assessment in children with intestinal failure (IF).

methodsWe conducted a prospective pilot study in children 14 years or younger with IF resulting from either short bowel syndrome or motility disorders. Bland-Altman analysis was used to examine the agreement between BIA and deuterium dilution in measuring total body water (TBW) and lean body mass (LBM), and between BIA and dual-energy x-ray absorptiometry (DXA) techniques in measuring LBM and fat mass (FM). FM and percent body fat (%BF) measurements by BIA and anthropometry were also compared in relation to those measured by deuterium dilution.

resultsFifteen children with IF, median (interquartile range) age 7.2 (5.0, 10.0) years, and 10 (67%) boys, were studied. BIA and deuterium dilution were in good agreement with a mean bias (limits of agreement) of 0.9 (-3.2 to 5.0) for TBW (L) and 0.1 (-5.4 to 5.6) for LBM (kg) measurements. The mean bias (limits) for FM (kg) and %BF measurements were 0.4 (-3.8 to 4.6) kg and 1.7 (-16.9 to 20.3)%, respectively. The limits of agreement were within 1 standard deviation of the mean bias in 12 of 14 (86%) subjects for TBW and LBM, and in 11 of 14 (79%) for FM and %BF measurements. Mean bias (limits) for LBM (kg) and FM (kg) between BIA and DXA were 1.6 (-3.0 to 6.3) kg and -0.1 (-3.2 to 3.1) kg, respectively. Mean bias (limits) for FM (kg) and %BF between anthropometry and deuterium dilution were 0.2 (-4.2 to 4.6) and -0.2 (-19.5 to 19.1), respectively. The limits of agreement were within 1 standard deviation of the mean bias in 10 of 14 (71%) subjects.

conclusionsIn children with IF, TBW and LBM measurements by multifrequency BIA method were in agreement with isotope dilution and DXA methods, with small mean bias and clinically acceptable limits of agreement. In comparison with deuterium dilution, BIA was comparable to anthropometry for FM and %BF assessments with small mean bias, but the limits of agreement were large. BIA is a reliable method for TBW and LBM assessments in population studies; however, its reliability in individual patients, especially for FM assessments, cannot be guaranteed.

Indexed as

Body CompositionDeuteriumElectric ImpedanceAbsorptiometry, PhotonAdiposityAnthropometryBody WaterChildChild, PreschoolFemaleHumansMalePilot ProjectsProspective StudiesShort Bowel SyndromeDeuterium

Identifiers

PMID24614122
PMCPMC4409423
OpenAlexW2052931541

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.