Evidence map›Paper›PMID 24614112›Full record

Trial reportPloS one2014

Effects of green tea extract on insulin resistance and glucagon-like peptide 1 in patients with type 2 diabetes and lipid abnormalities: a randomized, double-blinded, and placebo-controlled trial.

Chia-Yu Liu, Chien-Jung Huang, Lin-Huang Huang, I-Ju Chen, Jung-Peng Chiu, Chung-Hua Hsu

4 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 54 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 5 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01360567 phase3completednot on this map

Taipei City Hospital, Taipei, Taiwan

TypeinterventionalSponsorTaipei City HospitalRan2011 to 2012Enrolled102ConditionsType 2 Diabetes, HyperlipidemiaArmsGreen tea extract, Placebo
NCT02116517 phase3completednot on this map

Phase 3 Study; Effects of Green Tea Extract on Obese Women With High Level of Low Density Lipoprotein (LDL): a Randomized, Double-blinded, and Cross-over Placebo-controlled Clinical Trial

TypeinterventionalSponsorNational Yang Ming Chiao Tung UniversityRan2011 to 2013Enrolled73ConditionsObese, HyperlipidemiaArmsgreen tea extract, Placebo
NCT04532385 nacompletednot on this mapstarted 2018, after this paper: background citation

Effect of a 12-week Administration of Green Tea Extract on Lipids in Patients With Type 2 Diabetes

TypeinterventionalSponsorCentro Universitario de Ciencias de la Salud, MexicoRan2018 to 2019Enrolled20ConditionsDiabetes Mellitus, Type 2, Dyslipidemias, Arterial StiffnessArmsGreen tea extract, Placebo
NCT07240246 nacompletednot on this mapstarted 2025, after this paper: background citation

Effect of a Dietary Supplement (FitLine TopShape) on the Incretin Response

TypeinterventionalSponsorFFoQSI - Austrian Competence Centre for Feed and Food Quality, Safety & InnovationRan2025 to 2026Enrolled40ConditionsGLP-1, Obesity &Amp, Overweight, Dietary SupplementArmsIntervention: Dietary Supplement with Plant Extracts, Placebo
3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 5 syntheses or guidelines pooled it, 155 citations in OpenAlex.

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  16. Insights into the Therapeutic Use ofPharmaceuticals (Basel, Switzerland) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Chia-Yu LiuInstitute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Chinese Medicine, Branch of Linsen and Chinese Medicine, Taipei City Hospital, Taipei, Taiwan.
Chien-Jung HuangDepartment of Metabolism, Branch of Linsen and Chinese Medicine, Taipei City Hospital, Taipei, Taiwan.
Lin-Huang HuangInstitute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
I-Ju ChenInstitute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Chinese Medicine, Branch of Linsen and Chinese Medicine, Taipei City Hospital, Taipei, Taiwan.
Jung-Peng ChiuInstitute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Chinese Medicine, Branch of Linsen and Chinese Medicine, Taipei City Hospital, Taipei, Taiwan.
Chung-Hua HsuInstitute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Chinese Medicine, Branch of Linsen and Chinese Medicine, Taipei City Hospital, Taipei, Taiwan.
National Yang Ming Chiao Tung University · TWNational Yang Ming Chiao Tung University · TWTaipei City Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelledThe aim of this study is to investigate the effect of green tea extract on patients with type 2 diabetes mellitus and lipid abnormalities on glycemic and lipid profiles, and hormone peptides by a double-blinded, randomized and placebo-controlled clinical trial. This trial enrolled 92 subjects with type 2 diabetes mellitus and lipid abnormalities randomized into 2 arms, each arm comprising 46 participants. Of the participants, 39 in therapeutic arm took 500 mg green tea extract, three times a day, while 38 in control arm took cellulose with the same dose and frequency to complete the 16-week study. Anthropometrics measurements, glycemic and lipid profiles, safety parameters, and obesity-related hormone peptides were analyzed at screening and after 16-week course. Within-group comparisons showed that green tea extract caused a significant decrease in triglyceride and homeostasis model assessment of insulin resistance index after 16 weeks. Green tea extract also increased significantly high density lipoprotein cholesterol. The HOMA-IR index decreased from 5.4±3.9 to 3.5±2.0 in therapeutic arm only. Adiponectin, apolipoprotein A1, and apolipoprotein B100 increased significantly in both arms, but only glucagon-like peptide 1 increased in the therapeutic arm. However, only decreasing trend in triglyceride was found in between-group comparison. Our study suggested that green tea extract significantly improved insulin resistance and increased glucagon-like peptide 1 only in within-group comparison. The potential effects of green tea extract on insulin resistance and glucagon-like peptide 1 warrant further investigation.

trial registrationClinicalTrials.gov NCT01360567.

Indexed as

Insulin ResistanceDemographyDiabetes Mellitus, Type 2Double-Blind MethodFemaleGlucagon-Like Peptide 1HumansLipidsMaleMiddle AgedPlacebosPlant ExtractsGlucagon-Like Peptide 1LipidsPlacebosPlant Extracts

Identifiers

PMID24614112
PMCPMC3948786
OpenAlexW2031098261

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.