Evidence map›Paper›PMID 24613990›Full record

ArticleThorax2014

Interaction between gas cooking and GSTM1 null genotype in bronchial responsiveness: results from the European Community Respiratory Health Survey.

André F S Amaral, Adaikalavan Ramasamy, Francesc Castro-Giner, Cosetta Minelli, Simone Accordini, Inga-Cecilie Sørheim, Isabelle Pin, Manolis Kogevinas, Rain Jõgi, David J Balding and 8 more

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Thorax, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Reactivity between medium-sized silicon cluster and NOJournal of molecular modeling · 2021
    Article
  4. Indoor air concentrations of carbon dioxide (COEnvironmental geochemistry and health · 2020
    Article
  5. Article
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 12 institutions in 9 countries.

André F S AmaralRespiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College, London, UK MRC-PHE Centre for Environment & Health, London, UK.
Adaikalavan RamasamyRespiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College, London, UK.
Francesc Castro-GinerCentre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain Molecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Cosetta MinelliRespiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College, London, UK.
Simone AccordiniUnit of Epidemiology and Medical Statistics, Department of Public Health and Community Medicine, University of Verona, Verona, Italy.
Inga-Cecilie SørheimUniversity of Bergen, Bergen, Norway.
Isabelle PinPédiatrie, CHU de Grenoble, Institut Albert Bonniot, INSERM, Grenoble, France Université Joseph Fourier, Grenoble, France.
Manolis KogevinasCentre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.
Rain JõgiTartu University Hospital, Lung Clinic, Tartu, Estonia.
David J BaldingUCL Genetics Institute, University College London, London, UK.
Dan NorbäckDepartment of Medical Science, Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden.
Giuseppe VerlatoUnit of Epidemiology & Medical Statistics, Dept. of Public Health & Community Medicine, University of Verona, Verona, Italy.
Mario OlivieriUnit of Occupational Medicine, University Hospital of Verona, Verona, Italy.
Nicole Probst-HenschSwiss Tropical and Public Health Institute, Basel, Switzerland University of Basel, Basel, Switzerland.
Christer JansonDepartment of Medical Sciences, Respiratory Medicine and Allergology, Uppsala University, Uppsala, Sweden.
Jan-Paul ZockCentre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain Universitat Pompeu Fabra (UPF), Barcelona, Spain CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Spain.
Joachim HeinrichHelmholtz Zentrum München, German Research Centre for Environmental Health, Institute of Epidemiology I, Neuherberg, Germany.
Deborah L JarvisRespiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College, London, UK MRC-PHE Centre for Environment & Health, London, UK.
Imperial College London · GBUniversity of Verona · ITUppsala University · SECenter for Research in Environmental Epidemiology · ESCentre for Human Genetics · GBCentre Hospitalier Universitaire de Grenoble · FRCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública · ESHelmholtz Zentrum München · DESwiss Tropical and Public Health Institute · CHTartu University Hospital · EEUniversity College London · GBUniversity of Bergen · NO

Funding

Basal Ganglia and 5-HT in Ritualistic Social DisplaysR01MH062633 · NIMH · UNIVERSITY OF FLORIDA · PI BAXTER, LEWIS R · 2001 to 2005
$1.4M
NIMH NIH HHS R01 MH062633
6 · The paper itself

Abstract

backgroundIncreased bronchial responsiveness is characteristic of asthma. Gas cooking, which is a major indoor source of the highly oxidant nitrogen dioxide, has been associated with respiratory symptoms and reduced lung function. However, little is known about the effect of gas cooking on bronchial responsiveness and on how this relationship may be modified by variants in the genes GSTM1, GSTT1 and GSTP1, which influence antioxidant defences.

methodsThe study was performed in subjects with forced expiratory volume in one second at least 70% of predicted who took part in the multicentre European Community Respiratory Health Survey, had bronchial responsiveness assessed by methacholine challenge and had been genotyped for GSTM1, GSTT1 and GSTP1-rs1695. Information on the use of gas for cooking was obtained from interviewer-led questionnaires. Effect modification by genotype on the association between the use of gas for cooking and bronchial responsiveness was assessed within each participating country, and estimates combined using meta-analysis.

resultsOverall, gas cooking, as compared with cooking with electricity, was not associated with bronchial responsiveness (β=-0.08, 95% CI -0.40 to 0.25, p=0.648). However, GSTM1 significantly modified this effect (β for interaction=-0.75, 95% CI -1.16 to -0.33, p=4×10(-4)), with GSTM1 null subjects showing more responsiveness if they cooked with gas. No effect modification by GSTT1 or GSTP1-rs1695 genotypes was observed.

conclusionsIncreased bronchial responsiveness was associated with gas cooking among subjects with the GSTM1 null genotype. This may reflect the oxidant effects on the bronchi of exposure to nitrogen dioxide.

Indexed as

Natural GasAdultBronchial Provocation TestsCookingElectricityEuropean UnionFemaleForced Expiratory VolumeGenotypeGlutathione S-Transferase piGlutathione TransferaseHealth SurveysHumansMaleNitrogen DioxideGlutathione S-Transferase piglutathione S-transferase T1Glutathione TransferaseNatural GasNitrogen DioxideAsthma

Identifiers

PMID24613990
PMCPMC4033138
OpenAlexW2138326270

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.