ReviewCurrent opinion in psychiatry2014
Late-onset schizophrenia: do recent studies support categorizing LOS as a subtype of schizophrenia?
Review in Current opinion in psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 65 citations in OpenAlex.
- Associations between mosaic loss and schizophrenia or bipolar disorder of young age.Molecular psychiatry · 2026Article
- Is it Possible To Identify Patients After Their First Hospitalization for a Psychotic Disorder Who Do Not Use Anti-Psychotics and are Not Later Rehospitalized?Schizophrenia bulletin · 2026Article
- Risk Factors for Late-Onset Psychosis: A Case-Control Study.Schizophrenia bulletin · 2025Article
- Maternal immune activation induces sex-dependent behavioral differences in a rat model of schizophrenia.Frontiers in psychiatry · 2024Article
- Article
- Vascular Schizophrenia-like Psychosis in Older Adults.Journal of clinical medicine · 2023Article
- Differential Treatment Responses in Pakistani Schizophrenia Samples: Correlation with Sociodemographic Parameters, Drug Addiction, Attitude to the Treatment and Antipsychotic Agents.Brain sciences · 2023Article
- Deconstructing heterogeneity in schizophrenia through language: a semi-automated linguistic analysis and data-driven clustering approach.Schizophrenia (Heidelberg, Germany) · 2022Article
- Disentangling early and late onset of psychosis in women: identifying new targets for treatment.Archives of women's mental health · 2022Article
- Clinical Approaches to Late-Onset Psychosis.Journal of personalized medicine · 2022Review
- Polygenic Risk Scores for Subtyping of Schizophrenia.Schizophrenia research and treatment · 2020Article
- Cariprazine Safety in Adolescents and the Elderly: Analyses of Clinical Study Data.Frontiers in psychiatry · 2020Article
- Cognitive Functioning in Older Adults With Schizophrenia.Focus (American Psychiatric Publishing) · 2017Review
- Distressing Visual Hallucinations after Treatment with Trazodone.Case reports in psychiatry · 2017Article
- DSM-5 and Mental Disorders in Older Individuals: An Overview.Harvard review of psychiatryReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
purpose or reviewTo review recent literature about late-onset schizophrenia (LOS): schizophrenia with onset between ages 40 and 60 years. New findings are presented in the context of the previous literature. RECENT
findingsNewer studies continue to suggest that early-onset schizophrenia (EOS) and LOS share fundamental clinical features (i.e., positive symptoms, negative symptoms, functional deficits). One larger recent study confirmed earlier findings that LOS differs from EOS in several important ways, including predominance of women, lower severity of positive symptoms, and lower average antipsychotic dose requirement. However, this study did not find LOS patients were more likely to have the paranoid subtype or to have less severe negative symptoms compared with EOS patients. New neuroimaging and molecular studies are identifying possible differences in the underlying pathophysiology of EOS and schizophrenia developing in mid-life to late-life; however, more research is needed to confirm these findings and determine their significance. No studies evaluated treatment strategies specifically in LOS. SUMMARY: LOS continues to be an understudied area. Recent studies add support to the idea that LOS may be a distinct subtype of schizophrenia. Studies designed to elucidate the pathophysiology of LOS in comparison with EOS and to assess treatment strategies in this population are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.