Evidence map›Paper›PMID 24613913›Full record

ReviewSeminars in cell & developmental biology2014

Stem cell decisions: a twist of fate or a niche market?

Jens Januschke, Inke Näthke

Open access · hybridAbstract readReview
In one paragraph

Review in Seminars in cell & developmental biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Automatic Transformation and Integration to Improve Visualization and Discovery of Latent Effects in Imaging Data.Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America · 2020
    Article
  6. A role for the CXCR4-CXCL12 axis in the little skate, Leucoraja erinacea.American journal of physiology. Regulatory, integrative and comparative physiology · 2018
    Article
  7. Review
  8. Article
  9. Effect ofExperimental and therapeutic medicine · 2016
    Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jens JanuschkeCell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK. Electronic address: j.januschke@dundee.ac.uk.
Inke NäthkeCell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK. Electronic address: i.s.nathke@dundee.ac.uk.
University of Dundee · GB

Funding

Cancer Research UK 11243Cancer Research UK A11243Cancer Research UK C430/A11243Wellcome Trust 097945
6 · The paper itself

Abstract

Establishing and maintaining cell fate in the right place at the right time is a key requirement for normal tissue maintenance. Stem cells are at the core of this process. Understanding how stem cells balance self-renewal and production of differentiating cells is key for understanding the defects that underpin many diseases. Both, external cues from the environment and cell intrinsic mechanisms can control the outcome of stem cell division. The role of the orientation of stem cell division has emerged as an important mechanism for specifying cell fate decisions. Although, the alignment of cell divisions can dependent on spatial cues from the environment, maintaining stemness is not always linked to positioning of stem cells in a particular microenvironment or `niche'. Alternate mechanisms that could contribute to cellular memory include differential segregation of centrosomes in asymmetrically dividing cells.

Indexed as

Cell DifferentiationAnimalsCentrosomeChromosome SegregationCiliaHumansSignal TransductionSpindle ApparatusStem Cell NicheStem CellsAsymmetric cell divisionCentrosome segregationSpindle orientationStem cells

Identifiers

PMID24613913
PMCPMC4169664
OpenAlexW2040453897

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.