Evidence map›Paper›PMID 24613825›Full record

Trial reportOphthalmology2014

Visual acuity after cataract surgery in patients with age-related macular degeneration: age-related eye disease study 2 report number 5.

Age-Related Eye Disease Study 2 Research Group, Nancy Huynh, Benjamin P Nicholson, Elvira Agrón, Traci E Clemons, Susan B Bressler, Philip J Rosenfeld, Emily Y Chew

Open access · greenAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Ophthalmology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 6 pooled it
3.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 6 syntheses or guidelines pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Effect of Phacoemulsification on Visual Acuity and Macular Morphology in Patients with Wet Age-Related Macular Degeneration.Medical science monitor : international medical journal of experimental and clinical research · 2018
    Trial
  8. Review
  9. Review
  10. Article
  11. Article
  12. The Blue Light Hazard Versus Blue Light Hype.American journal of ophthalmology · 2022
    Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. MicroRNAs: new players in cataract.American journal of translational research · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Age-Related Eye Disease Study 2 Research Group
Nancy HuynhClinical Trials Branch, Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland.
Benjamin P NicholsonClinical Trials Branch, Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland.
Elvira AgrónClinical Trials Branch, Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland.
Traci E ClemonsEMMES Corporation, Rockville, Maryland.
Susan B BresslerWilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
Philip J RosenfeldBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida.
Emily Y ChewClinical Trials Branch, Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland. Electronic address: echew@nei.nih.gov.
National Eye Institute · USEmmes (United States) · USJohns Hopkins University · USNational Institutes of Health · USUniversity of Miami · US

Funding

Medical Retina FellowshipZIEEY000487 · NEI · NATIONAL EYE INSTITUTE · PI KEENAN, TIARNAN · 2009 to 2025
$6.6M
The Age-Related Eye Disease Study 2 (AREDS2)ZIAEY000485 · NEI · NATIONAL EYE INSTITUTE · PI CHEW, EMILY Y · 2009 to 2015
$990k
Intramural NIH HHS ZIA EY000485NEI NIH HHS N01-EY-5-0007PHS HHS HHS-N-260-2005-00007-C
6 · The paper itself

Abstract

objectiveTo evaluate visual acuity outcomes after cataract surgery in persons with varying degrees of severity of age-related macular degeneration (AMD).

designCohort study.

participantsA total of 1232 eyes of 793 participants who underwent cataract surgery during the Age-Related Eye Disease Study 2, a prospective, multicenter, randomized controlled trial of nutritional supplements for treatment of AMD.

methodsPreoperative and postoperative characteristics of participants who underwent cataract extraction during the 5-year trial were analyzed. Both clinical data and standardized red-reflex lens and fundus photographs were obtained at baseline and annually. Photographs were graded by a centralized reading center for cortical and posterior subcapsular lens opacities and for AMD severity. Cataract surgery was documented at annual study visits or by history during the 6-month telephone calls. Analyses were conducted using multivariate repeated-measures regression.

main outcome measuresChange in best-corrected visual acuity (BCVA) after cataract surgery compared with preoperative BCVA.

resultsAdjusting for age at time of surgery, gender, interval between preoperative and postoperative visits, and type and severity of cataract, the mean changes in visual acuity were as follows: eyes with mild AMD (n = 30) gained 11.2 letters (95% confidence interval [CI], 6.9-15.5), eyes with moderate AMD (n = 346) gained 11.1 letters (95% CI, 9.1-13.2), eyes with severe AMD (n = 462) gained 8.7 letters (95% CI, 6.7-10.7), eyes with noncentral geographic atrophy (n = 70) gained 8.9 letters (95% CI, 5.8-12.1), and eyes with advanced AMD (central geographic atrophy, neovascular disease, or both; n = 324) gained 6.8 letters (95% CI, 4.9-8.8). The visual acuity gain across all AMD severity groups was statistically significant from preoperative values (P < 0.0001).

conclusionsMean visual acuities improved significantly after cataract surgery across varying degrees of AMD severity.

Indexed as

Lens Implantation, IntraocularPhacoemulsificationAgedAged, 80 and overCataractCohort StudiesDietary SupplementsFatty Acids, Omega-3FemaleHumansLuteinMacular DegenerationMaleMiddle AgedProspective StudiesPseudophakiaFatty Acids, Omega-3LuteinVitaminsXanthophyllsZeaxanthins

Identifiers

PMID24613825
PMCPMC4047168
OpenAlexW2024299911

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.