Evidence map›Paper›PMID 24613094›Full record

Trial reportThe Journal of adolescent health : official publication of the Society for Adolescent Medicine2014

Percentage body fat by dual-energy X-ray absorptiometry is associated with menstrual recovery in adolescents with anorexia nervosa.

Sarah Pitts, Emily Blood, Amy Divasta, Catherine M Gordon

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in The Journal of adolescent health : official publication of the Society for Adolescent Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Pubertal Progression in Female Adolescents with Progeria.Journal of pediatric and adolescent gynecology · 2018
    Article
  7. Review
  8. Review
  9. Skeletal complications of eating disorders.Metabolism: clinical and experimental · 2015
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sarah PittsDivision of Adolescent/Young Adult Medicine and Division of Endocrinology, Boston Children's Hospital, Boston, Massachusetts. Electronic address: sarah.pitts@childrens.harvard.edu.
Emily BloodClinical Research Center and Division of Adolescent/Young Adult Medicine, Boston Children's Hospital, Boston, Massachusetts.
Amy DivastaDivision of Adolescent/Young Adult Medicine and Division of Gynecology, Boston Children's Hospital, Boston, Massachusetts.
Catherine M GordonDivision of Adolescent Medicine, Hasbro Children's Hospital, Providence, Rhode Island.

Funding

Harvard Clinical and Translational Science Center (UL1)UL1TR000170 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2012 to 2013
$31.4M
Effects of Adrenal and Gonadal HR in Young Women with ANR01HD043869 · NICHD · CHILDREN'S HOSPITAL BOSTON · PI GORDON, CATHERINE M. · 2004 to 2010
$1.7M
Effect of Adrenal and Gonadal Hormones on Bone Marrow and Appendicular BMDR01AR060829 · NIAMS · RHODE ISLAND HOSPITAL · PI GORDON, CATHERINE M. · 2011 to 2015
$1.4M
Biomechanical Stimulation & Skeletal Health in Adolescents with Anorexia NervosaK23HD060066 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI DIVASTA, AMY D · 2009 to 2013
$656k
NCATS NIH HHS 8UL1TR000170-05NCATS NIH HHS UL1 TR000170NIAMS NIH HHS R01 AR060829NICHD NIH HHS K23 HD060066NICHD NIH HHS R01 HD043869
6 · The paper itself

Abstract

purposeTo evaluate mediators of resumption of menses (ROM) in adolescents with anorexia nervosa (AN).

methodsAnthropometrics, body composition by dual-energy X-ray absorptiometry, hormonal studies, and responses to mental health screens were obtained at 6-month intervals for 18 months in 37 adolescents with AN randomized to the placebo arm of a double-blind treatment trial. Outcomes were compared between subjects with menstrual recovery and those without.

resultsTwenty-four subjects (65%) had ROM. Higher percentage body fat was associated with ROM (odds ratio, 1.19; 95% confidence interval, 1.06, 1.33; p < .01), as was body mass index and percent median body weight. Estradiol ≥30 ng/mL alone did not predict menses (p = .08) but was associated with ROM when coupled with percent mean body weight (odds ratio, 2.49; 95% confidence interval, 1.09, 5.65; p = .03). Changes in leptin, cortisol, and mental health were not associated with return of menses.

conclusionsPercentage body fat may be an additional, useful clinical assessment to follow in caring for adolescents with AN.

Indexed as

Absorptiometry, PhotonAdipose TissueAdolescentAmenorrheaAnorexia NervosaBody CompositionBody Mass IndexBody WeightDouble-Blind MethodFemaleFollow-Up StudiesHumansMenstruationAdolescentAmenorrheaAnorexia nervosaBody compositionLeptin

Identifiers

PMID24613094
PMCPMC4035435

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.