Observational studyAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2014
Glutathione S-transferase iso-enzymes in perfusate from pumped kidneys are associated with delayed graft function.
Observational study in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01848249 (Deceased Donor Urinary Biomarkers to Predict Kidney Transplant Outcomes), which is not on this map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Deceased Donor Urinary Biomarkers to Predict Kidney Transplant Outcomes
Who cites it
14 citing papers in PubMed, 37 citations in OpenAlex.
- Review
- Prolonged normothermic perfusion of the kidney prior to transplantation: a historically controlled, phase 1 cohort study.Nature communications · 2025Article
- Protein biomarkers in assessing kidney quality before transplantation‑current status and future perspectives (Review).International journal of molecular medicine · 2024Review
- Outcomes of Kidney Perfusion Techniques in Transplantation from Deceased Donors: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2023Review
- Extracellular Vesicles From Kidney Allografts Express miR-218-5p and Alter Th17/Treg Ratios.Frontiers in immunology · 2022Article
- Sense and Sensibilities of Organ Perfusion as a Kidney and Liver Viability Assessment Platform.Transplant international : official journal of the European Society for Organ Transplantation · 2022Review
- Recent Advances on Biomarkers of Early and Late Kidney Graft Dysfunction.International journal of molecular sciences · 2020Review
- Kidney Perfusion as an Organ Quality Assessment Tool-Are We Counting Our Chickens Before They Have Hatched?Journal of clinical medicine · 2020Review
- Urinary Biomarkers α-GST and π-GST for Evaluation and Monitoring in Living and Deceased Donor Kidney Grafts.Journal of clinical medicine · 2019Article
- Utility of Applying Quality Assessment Tools for Kidneys With KDPI ≥80.Transplantation · 2017Observational
- Associations of Perfusate Biomarkers and Pump Parameters With Delayed Graft Function and Deceased Donor Kidney Allograft Function.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2016Observational
- Delayed Graft Function 5 Months After Living Donor Kidney Transplantation.The American journal of case reports · 2016Article
- Associations of deceased donor kidney injury with kidney discard and function after transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2015Observational
- Clinical outcomes prediction in kidney transplantation by use of biomarkers from hypothermic machine perfusion.International braz j urol : official journal of the Brazilian Society of UrologyArticle
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 2 countries.
Funding
Abstract
Accurate and reliable assessment tools are needed in transplantation. The objective of this prospective, multi-center study was to determine the associations of the alpha and pi iso-enzymes of glutathione S-transferase (GST), measured from perfusate solution at the start and end (base and post) of kidney allograft machine perfusion, with subsequent delayed graft function (DGF). We also compared GST iso-enzyme perfusate levels from discarded versus transplanted kidneys. A total of 428 kidneys were linked to outcomes as recorded by the United Network of Organ Sharing. DGF, defined as any dialysis in the first week of transplant, occurred in 141 recipients (32%). Alpha- and pi-GST levels significantly increased during machine perfusion. The adjusted relative risks (95% confidence interval) of DGF with each log-unit increase in base and post pi-GST were 1.14 (1.0-1.3) and 1.36 (1.1-1.8), respectively. Alpha-GST was not independently associated with DGF. There were no significant differences in GST values between discarded and transplanted kidneys, though renal resistance was significantly higher in discarded kidneys. We found pi-GST at the end of machine perfusion to be independently associated with DGF. Further studies should elucidate the utility of GST for identifying injured kidneys with regard to organ allocation, discard and recipient management decisions.
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What OpenQuestion holds
Registered trials
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